Q01408

PR
Gene name
mus-18 (uve1, 5E6.270, NCU08850)
Protein name
UV-damage endonuclease
Names
UV-endonuclease, Mutagen-sensitive protein 18
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU08850
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-192 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q01408

Entry ID Method Resolution Chain Position Source
AF-Q01408-F1 Predicted AlphaFoldDB

No variants for Q01408

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q01408

No associated diseases with Q01408

No regional properties for Q01408

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q01408

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

3 GO annotations of biological process

Name Definition
mitochondrial DNA repair The process of restoring mitochondrial DNA after damage.
nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
response to UV Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSRKSKAAA LDTPQSESST FSSTLDSSAP SPARNLRRSG RNILQPSSEK DRDHEKRSGE
70 80 90 100 110 120
ELAGRMMGKD ANGHCLREGK EQEEGVKMAI EGLARMERRL QRATKRQKKQ LEEDGIPVPS
130 140 150 160 170 180
VVSRFPTAPY HHKSTNAEER EAKEPVLKTH SKDVEREAEI GVDDVVKMEP AATNIIEPED
190 200 210 220 230 240
AQDAAERGAA RPPAVNSSYL PLPWKGRLGY ACLNTYLRNA KPPIFSSRTC RMASIVDHRH
250 260 270 280 290 300
PLQFEDEPEH HLKNKPDKSK EPQDELGHKF VQELGLANAR DIVKMLCWNE KYGIRFLRLS
310 320 330 340 350 360
SEMFPFASHP VHGYKLAPFA SEVLAEAGRV AAELGHRLTT HPGQFTQLGS PRKEVVESAI
370 380 390 400 410 420
RDLEYHDELL SLLKLPEQQN RDAVMIIHMG GQFGDKAATL ERFKRNYARL SQSCKNRLVL
430 440 450 460 470 480
ENDDVGWTVH DLLPVCEELN IPMVLDYHHH NICFDPAHLR EGTLDISDPK LQERIANTWK
490 500 510 520 530 540
RKGIKQKMHY SEPCDGAVTP RDRRKHRPRV MTLPPCPPDM DLMIEAKDKE QAVFELMRTF
550 560 570 580 590 600
KLPGFEKIND MVPYDRDDEN RPAPPVKAPK KKKGGKRKRT TDEEAAEPEE VDTAADDVKD
610 620 630 640 650
APEGPKEVPE EERAMGGPYN RVYWPLGCEE WLKPKKREVK KGKVPEEVED EGEFDG