Q01387

PR
Gene name
ras-2 (B11N2.310, NCU03616)
Protein name
Protein ras-2
Names
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU03616
EC number
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

158-229 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q01387

Entry ID Method Resolution Chain Position Source
AF-Q01387-F1 Predicted AlphaFoldDB

1 variants for Q01387

Variant ID(s) Position Change Description Diseaes Association Provenance
121 S>F No

No associated diseases with Q01387

1 regional properties for Q01387

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 9 - 115 IPR005225

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GDP binding Binding to GDP, guanosine 5'-diphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVGNKQVLYK LVVLGDGGVG KTALTIQLCL EHFVETYDPT IEDSYRKQVV IDGQACMLEV
70 80 90 100 110 120
LDTAGQEEYT ALRDQWIRDG EGFVLVYSIS SRSSFARIKK FHHQIQRVKE STSSPSAYPG
130 140 150 160 170 180
SSPLAATNPS APVPIMLVGN KSDRVTEREV STQEGHALAR ELGCEFTEAS AKTRTNVEKA
190 200 210 220
FYDVVKQLRK QRQQGQSTPR ALPPSGNSKS EKYSGTEKPK RPRGKCLII