Q01290
Gene name |
vph-1 (vph1, B8J24.100, NCU03463) |
Protein name |
V-type proton ATPase subunit a |
Names |
V-ATPase a subunit, Vacuolar ATPase 98 kDa subunit, Vacuolar proton pump a subunit, Vacuolar proton translocating ATPase subunit a |
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU03463 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q01290
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q01290-F1 | Predicted | AlphaFoldDB |
No variants for Q01290
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q01290 | |||||
No associated diseases with Q01290
No regional properties for Q01290
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q01290 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| vacuolar proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. |
| vacuolar proton-transporting V-type ATPase, V0 domain | The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| vacuolar acidification | Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPKQDTPFR | SADMSMVQLY | ISNEIGREVC | NALGELGLVH | FRDLNSELSA | FQRAFTQDIR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLDNVERQLR | YFHSQMEKAG | IPLRKFDPDV | DILTPPTTTE | IDELAERAQT | LEQRVSSLNE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYETLKKREV | ELTEWRWVLR | EAGGFFDRAH | GNVEEIRAST | DNDDAPLLQD | VEQHNTAADV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ERSFSGMNIG | FVAGVIGRDR | VDAFERILWR | TLRGNLYMNQ | AEIPEPLIDP | TINEPVLKNV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FVIFAHGKEI | LAKIRRISES | MGAEVYNVDE | HSDLRRDQVH | EVNARLEDVQ | NVLRNTQQTL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EAELAQISQS | LSAWMITISK | EKAVYNTLNL | FSYDRARRTL | IAEGWCPTND | LPLIRSTLQD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VNNRAGLSVP | SIINEIRTNK | TPPTYLKTNK | FTEAFQTIVN | AYGTATYQEV | NPAIPVIVTF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PFLFAVMFGD | FGHALIMLCA | ALAMIYWEKP | LKKVTFELFA | MVFYGRYIVL | VMAVFSVYTG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LIYNDVFSKS | MTLFDSQWKW | VVPENFKEGM | TVKAVLREPN | GYRYPFGLDW | RWHGTENELL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FINSYKMKMA | IILGWAHMTY | SLCFSYINAR | HFKRPIDIWG | NFVPGMIFFQ | SIFGYLVLCI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IYKWSVDWFG | TGRQPPGLLN | MLIYMFLQPG | TLDGGVELYP | GQATVQVILL | LLAVIQVPIL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LFLKPFYLRW | ENNRARAKGY | RGIGERSRVS | ALDEDDEEDP | SNGDDYEGAA | MLTHDEHGDG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EHEEFEFGEV | MIHQVIHTIE | FCLNSVSHTA | SYLRLWALSL | AHQQLSAVLW | SMTMAKALES |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KGLGGAIFLV | VAFAMFFVLS | VIILIIMEGV | SAMLHSLRLA | WVESFSKFAE | FGGWPFTPFS |
| 850 | |||||
| FKQQLEESEE | LKEYIG |