Q00619

PR
Gene name
mam2 (SPAC11H11.04)
Protein name
Pheromone P-factor receptor
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC11H11.04
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

268-341 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q00619

Entry ID Method Resolution Chain Position Source
AF-Q00619-F1 Predicted AlphaFoldDB

4 variants for Q00619

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4780988_A_G 101 I>V No Jeffares_SNPs
I_4781150_C_A 155 H>N No Jeffares_SNPs
I_4781161_G_T 158 K>N No Jeffares_SNPs
I_4781177_A_T 164 T>S No Jeffares_SNPs

No associated diseases with Q00619

No regional properties for Q00619

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q00619

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
G protein-coupled receptor homodimeric complex A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mating projection membrane The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone.
plasma membrane of cell tip The portion of the plasma membrane surrounding the cell tip.

3 GO annotations of molecular function

Name Definition
mating-type factor pheromone receptor activity Combining with a mating-type factor pheromone to initiate a change in cell activity.
mating-type P-factor pheromone receptor activity Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus.
pheromone binding Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process.

3 GO annotations of biological process

Name Definition
pheromone-dependent signal transduction involved in conjugation with cellular fusion A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
positive regulation of conjugation with cellular fusion Any process that increases the rate or frequency of conjugation with cellular fusion.
positive regulation of pheromone response MAPK cascade Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRQPWWKDFT IPDASAIIHQ NITIVSIVGE IEVPVSTIDA YERDRLLTGM TLSAQLALGV
70 80 90 100 110 120
LTILMVCLLS SSEKRKHPVF VFNSASIVAM CLRAILNIVT ICSNSYSILV NYGFILNMVH
130 140 150 160 170 180
MYVHVFNILI LLLAPVIIFT AEMSMMIQVR IICAHDRKTQ RIMTVISACL TVLVLAFWIT
190 200 210 220 230 240
NMCQQIQYLL WLTPLSSKTI VGYSWPYFIA KILFAFSIIF HSGVFSYKLF RAILIRKKIG
250 260 270 280 290 300
QFPFGPMQCI LVISCQCLIV PATFTIIDSF IHTYDGFSSM TQCLLIISLP LSSLWASSTA
310 320 330 340
LKLQSMKTSS AQGETTEVSI RVDRTFDIKH TPSDDYSISD ESETKKWT