Q00576

PR
Gene name
PTDSS1 (PSSA)
Protein name
Phosphatidylserine synthase 1
Names
PSS-1, PtdSer synthase 1, Serine-exchange enzyme I
Species
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KEGG Pathway
EC number
2.7.8.29: Transferases for other substituted phosphate groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

394-471 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q00576

Entry ID Method Resolution Chain Position Source
AF-Q00576-F1 Predicted AlphaFoldDB

No variants for Q00576

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q00576

No associated diseases with Q00576

No regional properties for Q00576

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q00576

Functions

Description
EC Number 2.7.8.29 Transferases for other substituted phosphate groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Highly enriched in the mitochondria-associated membrane (MAM)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
L-serine-phosphatidylcholine phosphatidyltransferase activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline.
L-serine-phosphatidylethanolamine phosphatidyltransferase activity Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine.

1 GO annotations of biological process

Name Definition
phosphatidylserine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASCVGSRTL SKDDVNYRMH FRMINEQQVE DITIDFFYRP HTITLLSFTI VSLMYFAFTR
70 80 90 100 110 120
DDSVPEDNIW RGILSVIFFF LIISVLAFPN GPFTRPHPAL WRMVFGLSVL YFLFLVFLLF
130 140 150 160 170 180
LNFEQVKSLM YWLDPNLRYA TREADIMEYA VNCHVITWER IVSHFDIFAF GHFWGWAMKA
190 200 210 220 230 240
LLIRSYGLCW TISITWELTE LFFMHLLPNF AECWWDQVIL DILLCNGGGI WLGMVVCRFL
250 260 270 280 290 300
EMRTYHWASF KDIHTTTGKI KRAVLQFTPA SWTYVRWFDP KSSFQRVAGV YLFMIIWQLT
310 320 330 340 350 360
ELNTFFLKHI FVFQASHPLS WCRILFIGCI TAPTVRQYYA YLTDTQCKRV GTQCWVFGVI
370 380 390 400 410 420
GFLEAIVCIK FGQDLFSKTQ ILYVVFWLLC VAFTTFLCLY GMVWYAEHYG HREKTYSECE
430 440 450 460 470
DGTPEISWHH GKGSKGSEDS PPKHSSNNES HSSRRRNRHS KSKVTNGVGK K