Q00372

PR
Gene name
SNF1 (CAGL0M08910g)
Protein name
Carbon catabolite-derepressing protein kinase
Names
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0M08910g
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

178-200 (Activation loop from InterPro)

Target domain

39-290 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q00372

Entry ID Method Resolution Chain Position Source
AF-Q00372-F1 Predicted AlphaFoldDB

No variants for Q00372

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q00372

No associated diseases with Q00372

5 regional properties for Q00372

Type Name Position InterPro Accession
domain Protein kinase domain 39 - 290 IPR000719
active_site Serine/threonine-protein kinase, active site 157 - 169 IPR008271
domain Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain 322 - 373 IPR013896
binding_site Protein kinase, ATP binding site 45 - 68 IPR017441
domain AMPK, C-terminal adenylate sensor domain 480 - 605 IPR032270

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cellular bud neck septin ring A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange.
nuclear envelope lumen The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleotide-activated protein kinase complex A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

5 GO annotations of molecular function

Name Definition
AMP-activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
identical protein binding Binding to an identical protein or proteins.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

16 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cellular response to nitrogen starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
fungal-type cell wall assembly The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall.
invasive growth in response to glucose limitation A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
positive regulation of filamentous growth of a population of unicellular organisms in response to starvation Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation.
positive regulation of gluconeogenesis Any process that activates or increases the frequency, rate or extent of gluconeogenesis.
positive regulation of macroautophagy Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
positive regulation of pseudohyphal growth Any process that activates or increases the frequency, rate or extent of pseudohyphal growth.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of invasive growth in response to glucose limitation Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation.
response to endoplasmic reticulum stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
response to unfolded protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
single-species surface biofilm formation A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface.
trehalose catabolic process The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENKEHHHHH HHHHHHHSNG SYVSNKVSSL ADGSRVGNYQ IVKTLGEGSF GKVKLAYHVT
70 80 90 100 110 120
TGQKVALKII NKKVLAKSDM QGRIEREISY LRLLRHPHII KLYDVIKSKD EIIMVIEYAG
130 140 150 160 170 180
NELFDYIVQR NKMSEQEARR FFQQIISAVE YCHRHKIVHR DLKPENLLLD EHLNVKIADF
190 200 210 220 230 240
GLSNIMTDGN FLKTSCGSPN YAAPEVISGK LYAGPEVDVW SCGVILYVML CRRLPFDDES
250 260 270 280 290 300
IPVLFKNISN GVYTLPKFLS PGASDLIKRM LIVNPLNRIS IHEIMQDEWF KVDLAEYLVP
310 320 330 340 350 360
QDLKQQEQFN KKSGNEENVE EIDDEMVVTL SKTMGYDKDE IYEALESSED TPAYNEIRNA
370 380 390 400 410 420
YILIKDNKSL IKDMKQDNNV TQELDTFLSQ SPPTFQQNGD GMKASEDQKK KHSGRRLASS
430 440 450 460 470 480
VTQQRTFHQP PFMDQSKEED STISILPTSL PQIHRANMLA QGLPAASKIS PLVTKKSKTR
490 500 510 520 530 540
WHFGIRSRSY PLDVMGEIYI ALKNLGAEWA KPSEEDLWTI RVRWKYDSDE SRLIEDGVKK
550 560 570 580 590 600
IPNLMKIVIQ LFQIETNNYL VDFKFDGWES TYGDSTISTN MSEDEMSTFS AYPFLHLTTK
610
LIMELAVNSQ GN