Q00313

PR
Gene name
TOP1
Protein name
DNA topoisomerase 1
Names
DNA topoisomerase I
Species
Candida albicans (Yeast)
KEGG Pathway
EC number
5.6.2.1: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q00313

Entry ID Method Resolution Chain Position Source
AF-Q00313-F1 Predicted AlphaFoldDB

No variants for Q00313

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q00313

No associated diseases with Q00313

5 regional properties for Q00313

Type Name Position InterPro Accession
domain DNA topoisomerase I, DNA binding, eukaryotic-type 155 - 370 IPR008336
domain DNA topoisomerase I, eukaryotic-type 302 - 750 IPR013499
domain DNA topoisomerase I, catalytic core, eukaryotic-type 374 - 600 IPR013500
active_site DNA topoisomerase I, active site 723 - 741 IPR018521
domain Topoisomerase I C-terminal domain 709 - 778 IPR025834

Functions

Description
EC Number 5.6.2.1 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
replication fork protection complex A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.

9 GO annotations of biological process

Name Definition
DNA strand elongation involved in DNA replication The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
nuclear migration The directed movement of the nucleus to a specific location within a cell.
rDNA heterochromatin assembly The formation of heterochromatin at ribosomal DNA, characterized by the modified histone H3K9me3.
regulation of mitotic recombination Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
rRNA transcription The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNSSDEEDIA LSRLAKKSSS ITSASTYEDD EDDDIPLAKK SRKKRVESDY EEDEDEVPLK
70 80 90 100 110 120
KLSNGRAKKQ VKTETKVKKE PKSANKSKST SKKDTKVKKE KTTVKKESKA TSTKVKEESK
130 140 150 160 170 180
TQSDSQASVK SETPEEDQGY KWWEVNQEEE GDGYIKWQTL EHNGVMFPPP YEPLPSHVKL
190 200 210 220 230 240
YYNNKPVNLP PEAEEVAGFY GAMLETDHAK NPVFQKNFFN DFLEVLKECG GCGVEIKKFE
250 260 270 280 290 300
KLDFSKMYAH FEKLREEKKA MSREEKKRIK EEKEKEEEPY RTCYLNGRKE LVGNFRIEPP
310 320 330 340 350 360
GLFRGRGAHP KTGKLKRRVV SEQVTLNLGK DAKIPEPPAG HQWGEIRHDN EVTWLAMWKE
370 380 390 400 410 420
NISDSLKYVR FANNSSVKGQ SDFKKFETAR KLRDHVDSIR KDYTKMLKSE KMQDRQMATA
430 440 450 460 470 480
MYLIDVFALR AGGEKGEDEA DTVGCCSLRY EHVTLKPPNK VIFDLLGKDS IRFYQEVEVD
490 500 510 520 530 540
KQVFKNLRIF KKSPKQPGDD LFDRINPSLV NRQLQNYMKG LTAKVFRTYN ASKTMQDQID
550 560 570 580 590 600
IIENEGTVAE KVAKFNAANR TVAILCNHQR TVSKTHGDSV QRINDKLKKF MWQKIRLKKM
610 620 630 640 650 660
ILQLEPKLKK KDSKYFEEID DLIKEDIEHI HHTIIKRQRE QAKKKLERDN EKLKLEGKPL
670 680 690 700 710 720
LTESDIKDKL DKIDELEKEY QKELKTGKPI VTKNATVEKL KQQIETLENR ILNVSIQLKD
730 740 750 760 770
KEDNSEVSLG TSKMNYIDPR LIVMFSKKFD VPIEKLFTKT LREKFIWAIE SADENWRF