Q00043

PR
Gene name
HSP70
Protein name
Heat shock 70 kDa protein
Names
Species
Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

580-670 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q00043

Entry ID Method Resolution Chain Position Source
AF-Q00043-F1 Predicted AlphaFoldDB

No variants for Q00043

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q00043

No associated diseases with Q00043

3 regional properties for Q00043

Type Name Position InterPro Accession
conserved_site Heat shock protein 70, conserved site 7 - 14 IPR018181-1
conserved_site Heat shock protein 70, conserved site 195 - 208 IPR018181-2
conserved_site Heat shock protein 70, conserved site 333 - 347 IPR018181-3

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
fungal-type cell wall A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPAVGIDLG TTYSCVGIFR DDRIEIIAND QGNRTTPSFV AFTDTERLIG DAAKNQVAMN
70 80 90 100 110 120
PANTVFDAKR LIGRKFADPE VQADMKHFPF KITDKGGKPV IQVEFKGETK EFTPEEISSM
130 140 150 160 170 180
VLTKMRETAE AYLGGTVNNA VVTVPAYFND SQRQATKDAG LIAGLNVLRI INEPTAAAIA
190 200 210 220 230 240
YGLDKKADGE RNVLIFDLGG GTFDVSLLTI EEGIFEVKST AGDTHLGGED FDNRLVNHFV
250 260 270 280 290 300
SEFKRKFKKI SPAERARALR RSPTACERAK RTLSSAAQTS IEIDSLYEGI DFYTSITRAR
310 320 330 340 350 360
FEELCQDLFR STMEPVERVL RDAKIDKSSV HEIVLVGGST RIPRIQKLVS DFFNGKEPNK
370 380 390 400 410 420
SINPDEAVAY GAAVQAAILS GDTSSKSTNE ILLLDVAPLS LGIETAGGVM TPLIKRNTTI
430 440 450 460 470 480
PTKKSETFST FSDNQPGVLI QVFEGERART KDNNLLGKFE LTGIPRARGV PQIEVTFDVD
490 500 510 520 530 540
ANGIMNVSAL EKGTRKTNKI VITNDKGRLS KEEIERMLAE AEKYKAEDEA EASRIRPKNG
550 560 570 580 590 600
LESYAYSLRN SLRHSKVDEK LEAGDKEKLK SEIDKTVQWL DENQTATKEE YESQQKELEA
610 620 630 640 650 660
VANPIMMKFY AGGEGAPGGF PGAGGPGGFP GGPGAGHASG GGDDGPTVEE VDLKFPMLPL
670 680 690 700
PWQLSVRKMH RPFFLFLLFL IFLIFLILFL FYFFLPVRFN ESCFS