Q00006

PR
Gene name
PPP2R2B
Protein name
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Names
PP2A subunit B isoform B55-beta, PP2A subunit B isoform PR55-beta, PP2A subunit B isoform R2-beta, PP2A subunit B isoform beta
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q00006

Entry ID Method Resolution Chain Position Source
AF-Q00006-F1 Predicted AlphaFoldDB

No variants for Q00006

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q00006

No associated diseases with Q00006

7 regional properties for Q00006

Type Name Position InterPro Accession
repeat WD40 repeat 49 - 89 IPR001680-1
repeat WD40 repeat 131 - 170 IPR001680-2
repeat WD40 repeat 181 - 221 IPR001680-3
repeat WD40 repeat 240 - 278 IPR001680-4
repeat WD40 repeat 372 - 409 IPR001680-5
conserved_site Protein phosphatase 2A regulatory subunit PR55, conserved site 49 - 63 IPR018067-1
conserved_site Protein phosphatase 2A regulatory subunit PR55, conserved site 140 - 154 IPR018067-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytoskeleton
  • Membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

1 GO annotations of molecular function

Name Definition
protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
EFNHTGELLA TGDKGGRVVI FQREQESKNQ VHRRGEYNVY STFQSHEPEF DYLKSLEIEE
70 80 90 100 110 120
KINKIRWLPQ QNAAYFLLST NDKTVKLWKV SERDKRPEGY NLKDEEGRLR DPATITTLRV
130 140 150 160 170 180
PVLRPMDLMV EATPRRVFAN AHTYHINSIS VNSDYETYMS ADDLRINLWN FEITNQSFNI
190 200 210 220 230 240
VDIKPANMEE LTEVITAAEF HPHHCNTFVY SSSKGTIRLC DMRASALCDR HTKFFEEPED
250 260 270 280 290 300
PSNRSFFSEI ISSISDVKFS HSGRYIMTRD YLTVKVWDLN MENRPIETYQ VHDYLRSKLC
310 320 330 340 350 360
SLYENDCIFD KFECVWNGSD SVIMTGSYNN FFRMFDRNTK RDVTLEASRE NSKPRAILKP
370 380 390 400 410
RKVCVGGKRR KDEISVDSLD FSKKILHTAW HPSENIIAVA ATNNLYIFQD KVN