P9WQL9
Gene name |
drrA (Rv2936) |
Protein name |
Doxorubicin resistance ATP-binding protein DrrA |
Names |
|
Species |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
KEGG Pathway |
mtu:Rv2936 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P9WQL9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P9WQL9-F1 | Predicted | AlphaFoldDB |
No variants for P9WQL9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P9WQL9 | |||||
No associated diseases with P9WQL9
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| peptidoglycan-based cell wall | A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| biological process involved in interaction with host | An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. |
| daunorubicin transport | The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| doxorubicin transport | The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| response to antibiotic | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRNDDMAVVV | NGVRKTYGKG | KIVALDDVSF | KVRRGEVIGL | LGPNGAGKTT | MVDILSTLTR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PDAGSAIIAG | YDVVSEPAGV | RRSIMVTGQQ | VAVDDALSGE | QNLVLFGRLW | GLSKSAARKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AAELLEQFSL | VHAGKRRVGT | YSGGMRRRID | IACGLVVQPQ | VAFLDEPTTG | LDPRSRQAIW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLVASFKKLG | IATLLTTQYL | EEADALSDRI | ILIDHGIIIA | EGTANELKHR | AGDTFCEIVP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RDLKDLDAIV | AALGSLLPEH | HRAMLTPDSD | RITMPAPDGI | RMLVEAARRI | DEARIELADI |
| 310 | 320 | 330 | |||
| ALRRPSLDHV | FLAMTTDPTE | SLTHLVSGSA | R |