P9WQL8

PR
Gene name
drrA (MT3006)
Protein name
Doxorubicin resistance ATP-binding protein DrrA
Names
Species
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
KEGG Pathway
mtc:MT3006
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

286-331 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P9WQL8

Entry ID Method Resolution Chain Position Source
AF-P9WQL8-F1 Predicted AlphaFoldDB

No variants for P9WQL8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WQL8

No associated diseases with P9WQL8

3 regional properties for P9WQL8

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 8 - 240 IPR003439
domain AAA+ ATPase domain 34 - 245 IPR003593
conserved_site ABC transporter-like, conserved site 141 - 155 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

3 GO annotations of biological process

Name Definition
daunorubicin transport The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
doxorubicin transport The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRNDDMAVVV NGVRKTYGKG KIVALDDVSF KVRRGEVIGL LGPNGAGKTT MVDILSTLTR
70 80 90 100 110 120
PDAGSAIIAG YDVVSEPAGV RRSIMVTGQQ VAVDDALSGE QNLVLFGRLW GLSKSAARKR
130 140 150 160 170 180
AAELLEQFSL VHAGKRRVGT YSGGMRRRID IACGLVVQPQ VAFLDEPTTG LDPRSRQAIW
190 200 210 220 230 240
DLVASFKKLG IATLLTTQYL EEADALSDRI ILIDHGIIIA EGTANELKHR AGDTFCEIVP
250 260 270 280 290 300
RDLKDLDAIV AALGSLLPEH HRAMLTPDSD RITMPAPDGI RMLVEAARRI DEARIELADI
310 320 330
ALRRPSLDHV FLAMTTDPTE SLTHLVSGSA R