P9WQK3

PR
Gene name
ettA
Protein name
Energy-dependent translational throttle protein EttA
Names
Translational regulatory factor EttA
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2477c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

44-186 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P9WQK3

Entry ID Method Resolution Chain Position Source
7MSC EM 297 A x 1-558 PDB
7MSH EM 323 A x 1-558 PDB
7MSM EM 279 A x 1-558 PDB
7MSZ EM 310 A x 1-558 PDB
7MU0 X-ray 290 A A/B 1-558 PDB
AF-P9WQK3-F1 Predicted AlphaFoldDB

No variants for P9WQK3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WQK3

No associated diseases with P9WQK3

7 regional properties for P9WQK3

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 6 - 256 IPR003439-1
domain ABC transporter-like, ATP-binding domain 322 - 539 IPR003439-2
domain AAA+ ATPase domain 30 - 233 IPR003593-1
domain AAA+ ATPase domain 346 - 516 IPR003593-2
conserved_site ABC transporter-like, conserved site 160 - 174 IPR017871-1
conserved_site ABC transporter-like, conserved site 443 - 457 IPR017871-2
domain ABC-transporter extension domain 227 - 305 IPR032781

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Associates with ribosomes and polysomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ribosome binding Binding to a ribosome.
rRNA binding Binding to a ribosomal RNA.
tRNA binding Binding to a transfer RNA.

2 GO annotations of biological process

Name Definition
negative regulation of translational elongation Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEFIYTMKK VRKAHGDKVI LDDVTLSFYP GAKIGVVGPN GAGKSSVLRI MAGLDKPNNG
70 80 90 100 110 120
DAFLATGATV GILQQEPPLN EDKTVRGNVE EGMGDIKIKL DRFNEVAELM ATDYTDELME
130 140 150 160 170 180
EMGRLQEELD HADAWDLDAQ LEQAMDALRC PPADEPVTNL SGGERRRVAL CKLLLSKPDL
190 200 210 220 230 240
LLLDEPTNHL DAESVQWLEQ HLASYPGAIL AVTHDRYFLD NVAEWILELD RGRAYPYEGN
250 260 270 280 290 300
YSTYLEKKAE RLAVQGRKDA KLQKRLTEEL AWVRSGAKAR QAKSKARLQR YEEMAAEAEK
310 320 330 340 350 360
TRKLDFEEIQ IPVGPRLGNV VVEVDHLDKG YDGRALIKDL SFSLPRNGIV GVIGPNGVGK
370 380 390 400 410 420
TTLFKTIVGL ETPDSGSVKV GETVKLSYVD QARAGIDPRK TVWEVVSDGL DYIQVGQTEV
430 440 450 460 470 480
PSRAYVSAFG FKGPDQQKPA GVLSGGERNR LNLALTLKQG GNLILLDEPT NDLDVETLGS
490 500 510 520 530 540
LENALLNFPG CAVVISHDRW FLDRTCTHIL AWEGDDDNEA KWFWFEGNFG AYEENKVERL
550
GVDAARPHRV THRKLTRG