P9WQB3

PR
Gene name
leuA
Protein name
2-isopropylmalate synthase
Names
Alpha-IPM synthase, Alpha-isopropylmalate synthase
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv3710
EC number
2.3.3.13: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P9WQB3

Entry ID Method Resolution Chain Position Source
1SR9 X-ray 200 A A/B 1-644 PDB
3FIG X-ray 230 A A/B 3-644 PDB
3HPS X-ray 180 A A/B 1-644 PDB
3HPX X-ray 203 A A/B 1-425 PDB
3HPZ X-ray 220 A A/B 1-644 PDB
3HQ1 X-ray 170 A A/B 1-644 PDB
3U6W X-ray 221 A A/B 1-425 PDB
AF-P9WQB3-F1 Predicted AlphaFoldDB

No variants for P9WQB3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WQB3

No associated diseases with P9WQB3

5 regional properties for P9WQB3

Type Name Position InterPro Accession
domain Pyruvate carboxyltransferase 72 - 352 IPR000891
conserved_site Alpha-isopropylmalate/homocitrate synthase, conserved site 79 - 95 IPR002034-1
conserved_site Alpha-isopropylmalate/homocitrate synthase, conserved site 282 - 295 IPR002034-2
domain 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 474 - 643 IPR013709
domain LeuA, N-terminal catalytic TIM barrel domain 71 - 354 IPR039371

Functions

Description
EC Number 2.3.3.13 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
2-isopropylmalate synthase activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).
potassium ion binding Binding to a potassium ion (K+).
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTSESPDAY TESFGAHTIV KPAGPPRVGQ PSWNPQRASS MPVNRYRPFA EEVEPIRLRN
70 80 90 100 110 120
RTWPDRVIDR APLWCAVDLR DGNQALIDPM SPARKRRMFD LLVRMGYKEI EVGFPSASQT
130 140 150 160 170 180
DFDFVREIIE QGAIPDDVTI QVLTQCRPEL IERTFQACSG APRAIVHFYN STSILQRRVV
190 200 210 220 230 240
FRANRAEVQA IATDGARKCV EQAAKYPGTQ WRFEYSPESY TGTELEYAKQ VCDAVGEVIA
250 260 270 280 290 300
PTPERPIIFN LPATVEMTTP NVYADSIEWM SRNLANRESV ILSLHPHNDR GTAVAAAELG
310 320 330 340 350 360
FAAGADRIEG CLFGNGERTG NVCLVTLGLN LFSRGVDPQI DFSNIDEIRR TVEYCNQLPV
370 380 390 400 410 420
HERHPYGGDL VYTAFSGSHQ DAINKGLDAM KLDADAADCD VDDMLWQVPY LPIDPRDVGR
430 440 450 460 470 480
TYEAVIRVNS QSGKGGVAYI MKTDHGLSLP RRLQIEFSQV IQKIAEGTAG EGGEVSPKEM
490 500 510 520 530 540
WDAFAEEYLA PVRPLERIRQ HVDAADDDGG TTSITATVKI NGVETEISGS GNGPLAAFVH
550 560 570 580 590 600
ALADVGFDVA VLDYYEHAMS AGDDAQAAAY VEASVTIASP AQPGEAGRHA SDPVTIASPA
610 620 630 640
QPGEAGRHAS DPVTSKTVWG VGIAPSITTA SLRAVVSAVN RAAR