P9WQ77

PR
Gene name
lat (Rv3290c, MTCY71.30)
Protein name
Probable L-lysine-epsilon aminotransferase
Names
L-lysine aminotransferase, Lysine 6-aminotransferase
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv3290c
EC number
2.6.1.36: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-116 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P9WQ77

Entry ID Method Resolution Chain Position Source
2CIN X-ray 198 A A 1-449 PDB
2CJD X-ray 200 A A 1-449 PDB
2CJG X-ray 195 A A 1-449 PDB
2CJH X-ray 200 A A 1-449 PDB
2JJE X-ray 220 A A 1-449 PDB
2JJF X-ray 195 A A 1-449 PDB
2JJG X-ray 240 A A 1-449 PDB
2JJH X-ray 270 A A 1-449 PDB
AF-P9WQ77-F1 Predicted AlphaFoldDB

No variants for P9WQ77

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WQ77

No associated diseases with P9WQ77

No regional properties for P9WQ77

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P9WQ77

Functions

Description
EC Number 2.6.1.36 Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
4-aminobutyrate transaminase activity Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
L-lysine 6-transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

2 GO annotations of biological process

Name Definition
antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
gamma-aminobutyric acid catabolic process The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAVVKSVAL AGRPTTPDRV HEVLGRSMLV DGLDIVLDLT RSGGSYLVDA ITGRRYLDMF
70 80 90 100 110 120
TFVASSALGM NPPALVDDRE FHAELMQAAL NKPSNSDVYS VAMARFVETF ARVLGDPALP
130 140 150 160 170 180
HLFFVEGGAL AVENALKAAF DWKSRHNQAH GIDPALGTQV LHLRGAFHGR SGYTLSLTNT
190 200 210 220 230 240
KPTITARFPK FDWPRIDAPY MRPGLDEPAM AALEAEALRQ ARAAFETRPH DIACFVAEPI
250 260 270 280 290 300
QGEGGDRHFR PEFFAAMREL CDEFDALLIF DEVQTGCGLT GTAWAYQQLD VAPDIVAFGK
310 320 330 340 350 360
KTQVCGVMAG RRVDEVADNV FAVPSRLNST WGGNLTDMVR ARRILEVIEA EGLFERAVQH
370 380 390 400 410 420
GKYLRARLDE LAADFPAVVL DPRGRGLMCA FSLPTTADRD ELIRQLWQRA VIVLPAGADT
430 440
VRFRPPLTVS TAEIDAAIAA VRSALPVVT