P9WQ75

PR
Gene name
ilvE (Rv2210c, MTCY190.21c)
Protein name
Branched-chain-amino-acid aminotransferase
Names
BCAT
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2210c
EC number
2.6.1.42: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P9WQ75

Entry ID Method Resolution Chain Position Source
3HT5 X-ray 190 A A 1-368 PDB
5U3F X-ray 170 A A/B 1-368 PDB
AF-P9WQ75-F1 Predicted AlphaFoldDB

No variants for P9WQ75

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WQ75

No associated diseases with P9WQ75

1 regional properties for P9WQ75

Type Name Position InterPro Accession
conserved_site Aminotransferase, class IV, conserved site 240 - 273 IPR018300

Functions

Description
EC Number 2.6.1.42 Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

6 GO annotations of molecular function

Name Definition
branched-chain-amino-acid transaminase activity Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.
L-isoleucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
L-leucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid.
L-leucine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
L-valine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

7 GO annotations of biological process

Name Definition
branched-chain amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
branched-chain amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
isoleucine biosynthetic process The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
L-methionine salvage Any process that generates L-methionine from derivatives of it, without de novo synthesis.
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine.
valine biosynthetic process The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSGSLQFTV LRAVNPATDA QRESMLREPG FGKYHTDHMV SIDYAEGRGW HNARVIPYGP
70 80 90 100 110 120
IELDPSAIVL HYAQEVFEGL KAYRWADGSI VSFRADANAA RLRSSARRLA IPELPDAVFI
130 140 150 160 170 180
ESLRQLIAVD KAWVPGAGGE EALYLRPFIF ATEPGLGVRP ATQYRYLLIA SPAGAYFKGG
190 200 210 220 230 240
IAPVSVWVST EYVRACPGGT GAAKFGGNYA ASLLAQAEAA ENGCDQVVWL DAVERRYIEE
250 260 270 280 290 300
MGGMNIFFVL GSGGSARLVT PELSGSLLPG ITRDSLLQLA IDAGFAVEER RIDIDEWQKK
310 320 330 340 350 360
AAAGEITEVF ACGTAAVITP VARVRHGASE FRIADGQPGE VTMALRDTLT GIQRGTFADT
HGWMARLG