P9WP69

PR
Gene name
ctaC (Rv2200c, MTCY190.11c)
Protein name
Cytochrome c oxidase subunit 2
Names
Cytochrome aa3 subunit 2, Cytochrome c oxidase polypeptide II, Mtb92
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2200c
EC number
7.1.1.9: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P9WP69

Entry ID Method Resolution Chain Position Source
8HCR EM - E/Q 1-363 PDB
AF-P9WP69-F1 Predicted AlphaFoldDB

No variants for P9WP69

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WP69

No associated diseases with P9WP69

2 regional properties for P9WP69

Type Name Position InterPro Accession
binding_site Copper centre Cu(A) 252 - 306 IPR001505
domain Cytochrome c oxidase subunit II-like C-terminal 148 - 324 IPR002429

Functions

Description
EC Number 7.1.1.9 Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
respirasome The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

2 GO annotations of molecular function

Name Definition
copper ion binding Binding to a copper (Cu) ion.
cytochrome-c oxidase activity Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

1 GO annotations of biological process

Name Definition
ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTPRGPGRLQ RLSQCRPQRG SGGPARGLRQ LALAAMLGAL AVTVSGCSWS EALGIGWPEG
70 80 90 100 110 120
ITPEAHLNRE LWIGAVIASL AVGVIVWGLI FWSAVFHRKK NTDTELPRQF GYNMPLELVL
130 140 150 160 170 180
TVIPFLIISV LFYFTVVVQE KMLQIAKDPE VVIDITSFQW NWKFGYQRVN FKDGTLTYDG
190 200 210 220 230 240
ADPERKRAMV SKPEGKDKYG EELVGPVRGL NTEDRTYLNF DKVETLGTST EIPVLVLPSG
250 260 270 280 290 300
KRIEFQMASA DVIHAFWVPE FLFKRDVMPN PVANNSVNVF QIEEITKTGA FVGHCAEMCG
310 320 330 340 350 360
TYHSMMNFEV RVVTPNDFKA YLQQRIDGKT NAEALRAINQ PPLAVTTHPF DTRRGELAPQ
PVG