P9WNU2

PR
Gene name
MT2151
Protein name
5'-3' exonuclease
Names
Species
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
KEGG Pathway
mtc:MT2151
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

50-124 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P9WNU2

Entry ID Method Resolution Chain Position Source
AF-P9WNU2-F1 Predicted AlphaFoldDB

No variants for P9WNU2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WNU2

No associated diseases with P9WNU2

4 regional properties for P9WNU2

Type Name Position InterPro Accession
domain 5'-3' exonuclease 1 - 284 IPR002421
conserved_site Helix-hairpin-helix motif, class 2 192 - 227 IPR008918
domain DNA polymerase I-like, H3TH domain 194 - 278 IPR020045
domain 5'-3' exonuclease, alpha-helical arch, N-terminal 5 - 185 IPR020046

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.

1 GO annotations of biological process

Name Definition
DNA replication, Okazaki fragment processing The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRSPLVLLDG ASMWFRSFFG VPSSITAPDG RPVNAVRGFI DSMAVVITQQ RPNRLAVCLD
70 80 90 100 110 120
LDWRPQFRVD LIPSYKAHRV AEPEPNGQPD VEEVPDELTP QVDMIMELLD AFGIAMAGAP
130 140 150 160 170 180
GFEADDVLGT LATRERRDPV IVVSGDRDLL QVVADDPVPV RVLYLGRGLA KATLFGPAEV
190 200 210 220 230 240
AERYGLPAHR AGAAYAELAL LRGDPSDGLP GVPGVGEKTA ATLLARHGSL DQIMAAADDR
250 260 270 280 290 300
KTTMAKGLRT KLLAASAYIK AADRVVRVAT DAPVTLSTPT DRLPLVAADP ERTAELATRF
310
GVESSIARLQ KALDTLPG