P9WNT7

PR
Gene name
dnaE1 (dnaE, Rv1547, MTCY48.18c)
Protein name
DNA polymerase III subunit alpha
Names
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv1547
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

709-783 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P9WNT7

Entry ID Method Resolution Chain Position Source
5LEW X-ray 280 A A 7-933 PDB
7PU7 EM 290 A A 1-1184 PDB
8DJQ X-ray 280 A E/F/G/H 946-951 PDB
AF-P9WNT7-F1 Predicted AlphaFoldDB

No variants for P9WNT7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WNT7

No associated diseases with P9WNT7

5 regional properties for P9WNT7

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 11 - 78 IPR003141
domain PHP domain 12 - 198 IPR004013
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 320 - 590 IPR011708
domain DNA polymerase, helix-hairpin-helix motif 835 - 922 IPR029460
domain DNA polymerase III alpha subunit finger domain 593 - 762 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGSSAGSSF VHLHNHTEYS MLDGAAKITP MLAEVERLGM PAVGMTDHGN MFGASEFYNS
70 80 90 100 110 120
ATKAGIKPII GVEAYIAPGS RFDTRRILWG DPSQKADDVS GSGSYTHLTM MAENATGLRN
130 140 150 160 170 180
LFKLSSHASF EGQLSKWSRM DAELIAEHAE GIIITTGCPS GEVQTRLRLG QDREALEAAA
190 200 210 220 230 240
KWREIVGPDN YFLELMDHGL TIERRVRDGL LEIGRALNIP PLATNDCHYV TRDAAHNHEA
250 260 270 280 290 300
LLCVQTGKTL SDPNRFKFDG DGYYLKSAAE MRQIWDDEVP GACDSTLLIA ERVQSYADVW
310 320 330 340 350 360
TPRDRMPVFP VPDGHDQASW LRHEVDAGLR RRFPAGPPDG YRERAAYEID VICSKGFPSY
370 380 390 400 410 420
FLIVADLISY ARSAGIRVGP GRGSAAGSLV AYALGITDID PIPHGLLFER FLNPERTSMP
430 440 450 460 470 480
DIDIDFDDRR RGEMVRYAAD KWGHDRVAQV ITFGTIKTKA ALKDSARIHY GQPGFAIADR
490 500 510 520 530 540
ITKALPPAIM AKDIPLSGIT DPSHERYKEA AEVRGLIETD PDVRTIYQTA RGLEGLIRNA
550 560 570 580 590 600
GVHACAVIMS SEPLTEAIPL WKRPQDGAII TGWDYPACEA IGLLKMDFLG LRNLTIIGDA
610 620 630 640 650 660
IDNVRANRGI DLDLESVPLD DKATYELLGR GDTLGVFQLD GGPMRDLLRR MQPTGFEDVV
670 680 690 700 710 720
AVIALYRPGP MGMNAHNDYA DRKNNRQAIK PIHPELEEPL REILAETYGL IVYQEQIMRI
730 740 750 760 770 780
AQKVASYSLA RADILRKAMG KKKREVLEKE FEGFSDGMQA NGFSPAAIKA LWDTILPFAD
790 800 810 820 830 840
YAFNKSHAAG YGMVSYWTAY LKANYPAEYM AGLLTSVGDD KDKAAVYLAD CRKLGITVLP
850 860 870 880 890 900
PDVNESGLNF ASVGQDIRYG LGAVRNVGAN VVGSLLQTRN DKGKFTDFSD YLNKIDISAC
910 920 930 940 950 960
NKKVTESLIK AGAFDSLGHA RKGLFLVHSD AVDSVLGTKK AEALGQFDLF GSNDDGTGTA
970 980 990 1000 1010 1020
DPVFTIKVPD DEWEDKHKLA LEREMLGLYV SGHPLNGVAH LLAAQVDTAI PAILDGDVPN
1030 1040 1050 1060 1070 1080
DAQVRVGGIL ASVNRRVNKN GMPWASAQLE DLTGGIEVMF FPHTYSSYGA DIVDDAVVLV
1090 1100 1110 1120 1130 1140
NAKVAVRDDR IALIANDLTV PDFSNAEVER PLAVSLPTRQ CTFDKVSALK QVLARHPGTS
1150 1160 1170 1180
QVHLRLISGD RITTLALDQS LRVTPSPALM GDLKELLGPG CLGS