P9WNB1
Gene name |
eccCb1 |
Protein name |
ESX-1 secretion system protein EccCb1 |
Names |
ESX conserved component Cb1, Snm2 secretory protein, Type VII secretion system protein EccCb1, T7SS protein EccCb1 |
Species |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
KEGG Pathway |
mtu:Rv3871 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P9WNB1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6J19 | X-ray | 198 A | A | 315-591 | PDB |
| 6JD4 | X-ray | 210 A | A/B | 315-591 | PDB |
| AF-P9WNB1-F1 | Predicted | AlphaFoldDB |
No variants for P9WNB1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P9WNB1 | |||||
No associated diseases with P9WNB1
4 regional properties for P9WNB1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FtsK domain | 57 - 289 | IPR002543-1 |
| domain | FtsK domain | 359 - 545 | IPR002543-2 |
| domain | AAA+ ATPase domain | 76 - 254 | IPR003593-1 |
| domain | AAA+ ATPase domain | 368 - 550 | IPR003593-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| peptidoglycan-based cell wall | A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| biological process involved in interaction with host | An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. |
| evasion of host immune response | A process by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| protein secretion by the type VII secretion system | The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTAEPEVRTL | REVVLDQLGT | AESRAYKMWL | PPLTNPVPLN | ELIARDRRQP | LRFALGIMDE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PRRHLQDVWG | VDVSGAGGNI | GIGGAPQTGK | STLLQTMVMS | AAATHSPRNV | QFYCIDLGGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GLIYLENLPH | VGGVANRSEP | DKVNRVVAEM | QAVMRQRETT | FKEHRVGSIG | MYRQLRDDPS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QPVASDPYGD | VFLIIDGWPG | FVGEFPDLEG | QVQDLAAQGL | AFGVHVIIST | PRWTELKSRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RDYLGTKIEF | RLGDVNETQI | DRITREIPAN | RPGRAVSMEK | HHLMIGVPRF | DGVHSADNLV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EAITAGVTQI | ASQHTEQAPP | VRVLPERIHL | HELDPNPPGP | ESDYRTRWEI | PIGLRETDLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PAHCHMHTNP | HLLIFGAAKS | GKTTIAHAIA | RAICARNSPQ | QVRFMLADYR | SGLLDAVPDT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HLLGAGAINR | NSASLDEAVQ | ALAVNLKKRL | PPTDLTTAQL | RSRSWWSGFD | VVLLVDDWHM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IVGAAGGMPP | MAPLAPLLPA | AADIGLHIIV | TCQMSQAYKA | TMDKFVGAAF | GSGAPTMFLS |
| 550 | 560 | 570 | 580 | 590 | |
| GEKQEFPSSE | FKVKRRPPGQ | AFLVSPDGKE | VIQAPYIEPP | EEVFAAPPSA | G |