P9WNA5
Gene name |
eccC5 |
Protein name |
ESX-5 secretion system protein EccC5 |
Names |
ESX conserved component C5, Type VII secretion system protein EccC5, T7SS protein EccC5 |
Species |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
KEGG Pathway |
mtu:Rv1783 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
7 structures for P9WNA5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6J18 | X-ray | 200 A | A | 1116-1391 | PDB |
| 7NP7 | EM | 403 A | C1/C2/C3/C4/C5/C6 | 1-1391 | PDB |
| 7NPR | EM | 382 A | C1/C2/C3/C4/C5/C6 | 1-1391 | PDB |
| 7NPT | EM | 327 A | C1 | 1-1391 | PDB |
| 7NPU | EM | 448 A | C1/C2/C3/C4/C5/C6 | 1-1391 | PDB |
| 7NPV | EM | 666 A | C1/C2/C3/C4/C5/C6 | 1-1391 | PDB |
| AF-P9WNA5-F1 | Predicted | AlphaFoldDB |
No variants for P9WNA5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P9WNA5 | |||||
No associated diseases with P9WNA5
6 regional properties for P9WNA5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FtsK domain | 463 - 678 | IPR002543-1 |
| domain | FtsK domain | 824 - 1096 | IPR002543-2 |
| domain | FtsK domain | 1161 - 1354 | IPR002543-3 |
| domain | AAA+ ATPase domain | 491 - 669 | IPR003593-1 |
| domain | AAA+ ATPase domain | 868 - 1068 | IPR003593-2 |
| domain | AAA+ ATPase domain | 1170 - 1372 | IPR003593-3 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| peptidoglycan-based cell wall | A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRGFARPTP | EKPPVIKPEN | IVLSTPLSIP | PPEGKPWWLI | VVGVVVVGLL | GGMVAMVFAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSHVFGGIGS | IFPLFMMVGI | MMMMFRGMGG | GQQQMSRPKL | DAMRAQFMLM | LDMLRETAQE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SADSMDANYR | WFHPAPNTLA | AAVGSPRMWE | RKPDGKDLNF | GVVRVGVGMT | RPEVTWGEPQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NMPTDIELEP | VTGKALQEFG | RYQSVVYNLP | KMVSLLVEPW | YALVGEREQV | LGLMRAIICQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LAFSHGPDHV | QMIVVSSDLD | QWDWVKWLPH | FGDSRRHDAA | GNARMVYTSV | REFAAEQAEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FAGRGSFTPR | HASSSAQTPT | PHTVIIADVD | DPQWEYVISA | EGVDGVTFFD | LTGSSMWTDI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PERKLQFDKT | GVIEALPRDR | DTWMVIDDKA | WFFALTDQVS | IAEAEEFAQK | LAQWRLAEAY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EEIGQRVAHI | GARDILSYYG | IDDPGNIDFD | SLWASRTDTM | GRSRLRAPFG | NRSDNGELLF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LDMKSLDEGG | DGPHGVMSGT | TGSGKSTLVR | TVIESLMLSH | PPEELQFVLA | DLKGGSAVKP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FAGVPHVSRI | ITDLEEDQAL | MERFLDALWG | EIARRKAICD | SAGVDDAKEY | NSVRARMRAR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GQDMAPLPML | VVVIDEFYEW | FRIMPTAVDV | LDSIGRQGRA | YWIHLMMASQ | TIESRAEKLM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ENMGYRLVLK | ARTAGAAQAA | GVPNAVNLPA | QAGLGYFRKS | LEDIIRFQAE | FLWRDYFQPG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VSIDGEEAPA | LVHSIDYIRP | QLFTNSFTPL | EVSVGGPDIE | PVVAQPNGEV | LESDDIEGGE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DEDEEGVRTP | KVGTVIIDQL | RKIKFEPYRL | WQPPLTQPVA | IDDLVNRFLG | RPWHKEYGSA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| CNLVFPIGII | DRPYKHDQPP | WTVDTSGPGA | NVLILGAGGS | GKTTALQTLI | CSAALTHTPQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QVQFYCLAYS | STALTTVSRI | PHVGEVAGPT | DPYGVRRTVA | ELLALVRERK | RSFLECGIAS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| MEMFRRRKFG | GEAGPVPDDG | FGDVYLVIDN | YRALAEENEV | LIEQVNVIIN | QGPSFGVHVV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VTADRESELR | PPVRSGFGSR | IELRLAAVED | AKLVRSRFAK | DVPVKPGRGM | VAVNYVRLDS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DPQAGLHTLV | ARPALGSTPD | NVFECDSVVA | AVSRLTSAQA | PPVRRLPARF | GVEQVRELAS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| RDTRQGVGAG | GIAWAISELD | LAPVYLNFAE | NSHLMVTGRR | ECGRTTTLAT | IMSEIGRLYA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| PGASSAPPPA | PGRPSAQVWL | VDPRRQLLTA | LGSDYVERFA | YNLDGVVAMM | GELAAALAGR |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| EPPPGLSAEE | LLSRSWWSGP | EIFLIVDDIQ | QLPPGFDSPL | HKAVPFVNRA | ADVGLHVIVT |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| RTFGGWSSAG | SDPMLRALHQ | ANAPLLVMDA | DPDEGFIRGK | MKGGPLPRGR | GLLMAEDTGV |
| 1390 | |||||
| FVQVAATEVR | R |