P9WKK9

PR
Gene name
leuB
Protein name
3-isopropylmalate dehydrogenase
Names
3-IPM-DH, Beta-IPM dehydrogenase, IMDH
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2995c
EC number
1.1.1.85: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

231-301 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P9WKK9

Entry ID Method Resolution Chain Position Source
1W0D X-ray 165 A A/B/C/D 2-336 PDB
2G4O X-ray 200 A A/B/C/D 2-336 PDB
AF-P9WKK9-F1 Predicted AlphaFoldDB

No variants for P9WKK9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WKK9

No associated diseases with P9WKK9

4 regional properties for P9WKK9

Type Name Position InterPro Accession
domain Pyruvate carboxyltransferase 5 - 274 IPR000891
conserved_site Alpha-isopropylmalate/homocitrate synthase, conserved site 12 - 28 IPR002034-1
conserved_site Alpha-isopropylmalate/homocitrate synthase, conserved site 199 - 212 IPR002034-2
domain 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 371 - 504 IPR013709

Functions

Description
EC Number 1.1.1.85 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3-isopropylmalate dehydrogenase activity Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
magnesium ion binding Binding to a magnesium (Mg) ion.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

1 GO annotations of biological process

Name Definition
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLAIIAGDG IGPEVTAEAV KVLDAVVPGV QKTSYDLGAR RFHATGEVLP DSVVAELRNH
70 80 90 100 110 120
DAILLGAIGD PSVPSGVLER GLLLRLRFEL DHHINLRPAR LYPGVASPLS GNPGIDFVVV
130 140 150 160 170 180
REGTEGPYTG NGGAIRVGTP NEVATEVSVN TAFGVRRVVA DAFERARRRR KHLTLVHKTN
190 200 210 220 230 240
VLTFAGGLWL RTVDEVGECY PDVEVAYQHV DAATIHMITD PGRFDVIVTD NLFGDIITDL
250 260 270 280 290 300
AAAVCGGIGL AASGNIDATR ANPSMFEPVH GSAPDIAGQG IADPTAAIMS VALLLSHLGE
310 320 330
HDAAARVDRA VEAHLATRGS ERLATSDVGE RIAAAL