P9WKK7

PR
Gene name
icl (Rv0467, MTV038.11)
Protein name
Isocitrate lyase
Names
ICL, Isocitrase, Isocitratase
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv0467
EC number
4.1.3.1: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

383-428 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

12 structures for P9WKK7

Entry ID Method Resolution Chain Position Source
1F61 X-ray 200 A A/B 2-428 PDB
1F8I X-ray 225 A A/B/C/D 2-428 PDB
1F8M X-ray 180 A A/B/C/D 2-428 PDB
5DQL X-ray 178 A A/B/C/D 1-428 PDB
6C4A X-ray 180 A A/B/C/D/E/F/G/H 1-428 PDB
6C4C X-ray 220 A A/B/C/D/E/F/G/H 1-428 PDB
6VB9 X-ray 188 A A/B/C/D 1-428 PDB
6WSI X-ray 175 A A/B/C/D 1-428 PDB
6XPP X-ray 155 A A/B/C/D 1-428 PDB
7CP1 X-ray 258 A A/B 1-428 PDB
7RB1 X-ray 190 A A/B/C/D 1-428 PDB
AF-P9WKK7-F1 Predicted AlphaFoldDB

No variants for P9WKK7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WKK7

No associated diseases with P9WKK7

1 regional properties for P9WKK7

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 189 - 194 IPR018523

Functions

Description
EC Number 4.1.3.1 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
metal ion binding Binding to a metal ion.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
zymogen binding Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.

5 GO annotations of biological process

Name Definition
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle.
response to host immune response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVVGTPKSA EQIQQEWDTN PRWKDVTRTY SAEDVVALQG SVVEEHTLAR RGAEVLWEQL
70 80 90 100 110 120
HDLEWVNALG ALTGNMAVQQ VRAGLKAIYL SGWQVAGDAN LSGHTYPDQS LYPANSVPQV
130 140 150 160 170 180
VRRINNALQR ADQIAKIEGD TSVENWLAPI VADGEAGFGG ALNVYELQKA LIAAGVAGSH
190 200 210 220 230 240
WEDQLASEKK CGHLGGKVLI PTQQHIRTLT SARLAADVAD VPTVVIARTD AEAATLITSD
250 260 270 280 290 300
VDERDQPFIT GERTREGFYR TKNGIEPCIA RAKAYAPFAD LIWMETGTPD LEAARQFSEA
310 320 330 340 350 360
VKAEYPDQML AYNCSPSFNW KKHLDDATIA KFQKELAAMG FKFQFITLAG FHALNYSMFD
370 380 390 400 410 420
LAYGYAQNQM SAYVELQERE FAAEERGYTA TKHQREVGAG YFDRIATTVD PNSSTTALTG
STEEGQFH