P9WKD9
Gene name |
mku (Rv0937c) |
Protein name |
Non-homologous end joining protein Ku |
Names |
Mt-Ku |
Species |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
KEGG Pathway |
mtu:Rv0937c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P9WKD9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P9WKD9-F1 | Predicted | AlphaFoldDB |
No variants for P9WKD9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P9WKD9 | |||||
No associated diseases with P9WKD9
5 regional properties for P9WKD9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GMP synthase, C-terminal | 213 - 525 | IPR001674 |
| domain | GMP synthase, glutamine amidotransferase | 10 - 204 | IPR004739 |
| domain | Glutamine amidotransferase | 12 - 200 | IPR017926 |
| domain | NAD/GMP synthase | 216 - 257 | IPR022310 |
| domain | GMP synthetase ATP pyrophosphatase domain | 208 - 400 | IPR025777 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA helicase complex | A protein complex that possesses DNA helicase activity. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| double-stranded DNA binding | Binding to double-stranded DNA. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| double-strand break repair via nonhomologous end joining | The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. |
| positive regulation of ligase activity | Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRAIWTGSIA | FGLVNVPVKV | YSATADHDIR | FHQVHAKDNG | RIRYKRVCEA | CGEVVDYRDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARAYESGDGQ | MVAITDDDIA | SLPEERSREI | EVLEFVPAAD | VDPMMFDRSY | FLEPDSKSSK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYVLLAKTLA | ETDRMAIVHF | TLRNKTRLAA | LRVKDFGKRE | VMMVHTLLWP | DEIRDPDFPV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDQKVEIKPA | ELKMAGQVVD | SMADDFNPDR | YHDTYQEQLQ | ELIDTKLEGG | QAFTAEDQPR |
| 250 | 260 | 270 | |||
| LLDEPEDVSD | LLAKLEASVK | ARSKANSNVP | TPP |