P9WKD8

PR
Gene name
mku (MT0964)
Protein name
Non-homologous end joining protein Ku
Names
Mt-Ku
Species
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
KEGG Pathway
mtc:MT0964
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

178-273 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P9WKD8

Entry ID Method Resolution Chain Position Source
AF-P9WKD8-F1 Predicted AlphaFoldDB

No variants for P9WKD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WKD8

No associated diseases with P9WKD8

2 regional properties for P9WKD8

Type Name Position InterPro Accession
domain Protein kinase domain 369 - 626 IPR000719
active_site Serine/threonine-protein kinase, active site 490 - 502 IPR008271

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
double-stranded DNA binding Binding to double-stranded DNA.

2 GO annotations of biological process

Name Definition
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRAIWTGSIA FGLVNVPVKV YSATADHDIR FHQVHAKDNG RIRYKRVCEA CGEVVDYRDL
70 80 90 100 110 120
ARAYESGDGQ MVAITDDDIA SLPEERSREI EVLEFVPAAD VDPMMFDRSY FLEPDSKSSK
130 140 150 160 170 180
SYVLLAKTLA ETDRMAIVHF TLRNKTRLAA LRVKDFGKRE VMMVHTLLWP DEIRDPDFPV
190 200 210 220 230 240
LDQKVEIKPA ELKMAGQVVD SMADDFNPDR YHDTYQEQLQ ELIDTKLEGG QAFTAEDQPR
250 260 270
LLDEPEDVSD LLAKLEASVK ARSKANSNVP TPP