P9WKB5

PR
Gene name
Rv2285 (MTCY339.25c)
Protein name
Putative diacyglycerol O-acyltransferase Rv2285
Names
Putative triacylglycerol synthase Rv2285
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2285
EC number
2.3.1.20: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

126-247 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P9WKB5

Entry ID Method Resolution Chain Position Source
AF-P9WKB5-F1 Predicted AlphaFoldDB

No variants for P9WKB5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WKB5

No associated diseases with P9WKB5

2 regional properties for P9WKB5

Type Name Position InterPro Accession
domain O-acyltransferase, WSD1-like, N-terminal 4 - 256 IPR004255
domain O-acyltransferase WSD1, C-terminal 295 - 439 IPR009721

Functions

Description
EC Number 2.3.1.20 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
diacylglycerol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
long-chain-alcohol O-fatty-acyltransferase activity Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA.

5 GO annotations of biological process

Name Definition
glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
glycerolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to nitric oxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLLSPLDQM FARMEAPRTP MHIGAFAVFD LPKGAPRRFI RDLYEAISQL AFLPFPFDSV
70 80 90 100 110 120
IAGGASMAYW RQVQPDPSYH VRLSALPYPG TGRDLGALVE RLHSTPLDMA KPLWELHLIE
130 140 150 160 170 180
GLTGRQFAMY FKAHHCAVDG LGGVNLIKSW LTTDPEAPPG SGKPEPFGDD YDLASVLAAA
190 200 210 220 230 240
TTKRAVEGVS AVSELAGRLS SMVLGANSSV RAALTTPRTP FNTRVNRHRR LAVQVLKLPR
250 260 270 280 290 300
LKAVAHATDC TVNDVILASV GGACRRYLQE LGDLPTNTLT ASVPVGFERD ADTVNAASGF
310 320 330 340 350 360
VAPLGTSIED PVARLTTISA STTRGKAELL AMSPNALQHY SVFGLLPIAV GQKTGALGVI
370 380 390 400 410 420
PPLFNFTVSN VVLSKDPLYL SGAKLDVIVP MSFLCDGYGL NVTLVGYTDK VVLGFLGCRD
430 440
TLPHLQRLAQ YTGAAFEELE TAALP