P9WJN5

PR
Gene name
mscL
Protein name
Large-conductance mechanosensitive channel
Names
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv0985c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

96-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P9WJN5

Entry ID Method Resolution Chain Position Source
2OAR X-ray 350 A A/B/C/D/E 1-151 PDB
6CTD X-ray 580 A A/B/C/D/E/F/G/H/I/J 1-101 PDB
AF-P9WJN5-F1 Predicted AlphaFoldDB

No variants for P9WJN5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WJN5

No associated diseases with P9WJN5

4 regional properties for P9WJN5

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 346 - 582 IPR003439
domain AAA+ ATPase domain 372 - 559 IPR003593
domain ABC transporter type 1, transmembrane domain 32 - 314 IPR011527
conserved_site ABC transporter-like, conserved site 485 - 499 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.
identical protein binding Binding to an identical protein or proteins.
mechanosensitive ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.

3 GO annotations of biological process

Name Definition
cellular water homeostasis Any process involved in the maintenance of an internal steady state of water within a cell.
ion transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKGFKEFLA RGNIVDLAVA VVIGTAFTAL VTKFTDSIIT PLINRIGVNA QSDVGILRIG
70 80 90 100 110 120
IGGGQTIDLN VLLSAAINFF LIAFAVYFLV VLPYNTLRKK GEVEQPGDTQ VVLLTEIRDL
130 140 150
LAQTNGDSPG RHGGRGTPSP TDGPRASTES Q