P9WJI7

PR
Gene name
pncB2 (Rv0573c)
Protein name
Nicotinate phosphoribosyltransferase pncB2
Names
NAPRTase pncB2
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv0573c
EC number
6.3.4.21: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

103-176 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P9WJI7

Entry ID Method Resolution Chain Position Source
AF-P9WJI7-F1 Predicted AlphaFoldDB

No variants for P9WJI7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WJI7

No associated diseases with P9WJI7

9 regional properties for P9WJI7

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 18 - 147 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 343 - 476 IPR001247-2
domain S1 domain 638 - 717 IPR003029
domain K Homology domain 572 - 637 IPR004087
domain K Homology domain, type 1 576 - 632 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 153 - 214 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 480 - 548 IPR015847-2
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 245 - 340 IPR015848
domain RNA-binding domain, S1 640 - 717 IPR022967

Functions

Description
EC Number 6.3.4.21 Other carbon--nitrogen ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
nicotinamide phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide.
nicotinate phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate.

4 GO annotations of biological process

Name Definition
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
NAD salvage Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam).
response to host Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAIRQHVGAL FTDLYEVTMA QAYWAERMSG TAVFEIFFRK LPPGRSYIMA AGLADVVEFL
70 80 90 100 110 120
EAFRFDEQDL RYLRGLGQFS DEFLRWLAGV RFTGDVWAAP EGTVIFPNEP AVQLIAPIIE
130 140 150 160 170 180
AQLVETFVLN QIHLQSVLAS KAARVVAAAR GRPVVDFGAR RAHGTDAACK VARTSYLAGA
190 200 210 220 230 240
AGTSNLLAAR QYGIPTFGTM AHSFVQAFDS EVAAFEAFAR LYPATMLLVD TYDTLRGVDH
250 260 270 280 290 300
VIELAKRLGN RFDVRAVRLD SGDLDELSKA TRARLDTAGL EQVEIFASSG LDENRIAALL
310 320 330 340 350 360
AARCPIDGFG VGTQLVVAQD APALDMAYKL VAYDGSGRTK FSSGKVIYPG RKQVFRKLEH
370 380 390 400 410 420
GVFCGDTLGE HGENLPGDPL LVPIMTNGRR IRQHAPTLDG ARDWARQQID ALPPELRSLE
430 440 450 460
DTGYSYPVAV SDRIVGELAR LRHADTAEAH PGSNVVGAKA KRP