P9WJ03

PR
Gene name
sir (nirA, Rv2391)
Protein name
Sulfite reductase [ferredoxin]
Names
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2391
EC number
1.8.7.1: With an iron-sulfur protein as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P9WJ03

Entry ID Method Resolution Chain Position Source
1ZJ8 X-ray 280 A A/B 3-555 PDB
1ZJ9 X-ray 290 A A/B 3-555 PDB
AF-P9WJ03-F1 Predicted AlphaFoldDB

No variants for P9WJ03

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WJ03

No associated diseases with P9WJ03

6 regional properties for P9WJ03

Type Name Position InterPro Accession
domain Nitrite/Sulfite reductase ferredoxin-like domain 92 - 152 IPR005117-1
domain Nitrite/Sulfite reductase ferredoxin-like domain 338 - 400 IPR005117-2
binding_site Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site 412 - 430 IPR006066-1
binding_site Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site 461 - 479 IPR006066-2
domain Nitrite/sulphite reductase 4Fe-4S domain 162 - 312 IPR006067-1
domain Nitrite/sulphite reductase 4Fe-4S domain 413 - 540 IPR006067-2

Functions

Description
EC Number 1.8.7.1 With an iron-sulfur protein as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.

5 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.
sulfite reductase (ferredoxin) activity Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin.
sulfite reductase activity Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor.

1 GO annotations of biological process

Name Definition
sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTARPAKAR NEGQWALGHR EPLNANEELK KAGNPLDVRE RIENIYAKQG FDSIDKTDLR
70 80 90 100 110 120
GRFRWWGLYT QREQGYDGTW TGDDNIDKLE AKYFMMRVRC DGGALSAAAL RTLGQISTEF
130 140 150 160 170 180
ARDTADISDR QNVQYHWIEV ENVPEIWRRL DDVGLQTTEA CGDCPRVVLG SPLAGESLDE
190 200 210 220 230 240
VLDPTWAIEE IVRRYIGKPD FADLPRKYKT AISGLQDVAH EINDVAFIGV NHPEHGPGLD
250 260 270 280 290 300
LWVGGGLSTN PMLAQRVGAW VPLGEVPEVW AAVTSVFRDY GYRRLRAKAR LKFLIKDWGI
310 320 330 340 350 360
AKFREVLETE YLKRPLIDGP APEPVKHPID HVGVQRLKNG LNAVGVAPIA GRVSGTILTA
370 380 390 400 410 420
VADLMARAGS DRIRFTPYQK LVILDIPDAL LDDLIAGLDA LGLQSRPSHW RRNLMACSGI
430 440 450 460 470 480
EFCKLSFAET RVRAQHLVPE LERRLEDINS QLDVPITVNI NGCPNSCARI QIADIGFKGQ
490 500 510 520 530 540
MIDDGHGGSV EGFQVHLGGH LGLDAGFGRK LRQHKVTSDE LGDYIDRVVR NFVKHRSEGE
550
RFAQWVIRAE EDDLR