P9WI81

PR
Gene name
pknB (Rv0014c, MTCY10H4.14c)
Protein name
Serine/threonine-protein kinase PknB
Names
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv0014c
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

277-347 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

25 structures for P9WI81

Entry ID Method Resolution Chain Position Source
1MRU X-ray 300 A A/B 1-308 PDB
1O6Y X-ray 220 A A 1-279 PDB
2FUM X-ray 289 A A/B/C/D 1-279 PDB
2KUD NMR - A 355-491 PDB
2KUE NMR - A 423-557 PDB
2KUF NMR - A 491-626 PDB
2KUI NMR - A 355-626 PDB
3F61 X-ray 180 A A 1-308 PDB
3F69 X-ray 280 A A/B 1-308 PDB
3ORI X-ray 200 A A/B/C/D 1-308 PDB
3ORK X-ray 160 A A 1-308 PDB
3ORL X-ray 290 A A 1-308 PDB
3ORM X-ray 250 A A 1-308 PDB
3ORO X-ray 190 A A 1-308 PDB
3ORP X-ray 210 A A 1-308 PDB
3ORT X-ray 190 A A 1-308 PDB
3OUV X-ray 200 A A 489-558 PDB
5E0Y X-ray 200 A A 558-626 PDB
5E0Z X-ray 200 A A 491-626 PDB
5E10 X-ray 180 A A 360-491 PDB
5E12 X-ray 221 A A/B 423-626 PDB
5U94 X-ray 220 A A 1-280 PDB
6B2P X-ray 301 A A 1-279 PDB
6I2P X-ray 237 A A/B 1-279 PDB
AF-P9WI81-F1 Predicted AlphaFoldDB

No variants for P9WI81

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WI81

No associated diseases with P9WI81

7 regional properties for P9WI81

Type Name Position InterPro Accession
domain Protein kinase domain 11 - 274 IPR000719
domain PASTA domain 356 - 422 IPR005543-1
domain PASTA domain 423 - 490 IPR005543-2
domain PASTA domain 491 - 557 IPR005543-3
domain PASTA domain 558 - 626 IPR005543-4
active_site Serine/threonine-protein kinase, active site 134 - 146 IPR008271
binding_site Protein kinase, ATP binding site 17 - 40 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
  • Localizes to septum and cell poles (PubMed:21829358)
  • The localization of PknB to the cell membrane is essential for cell survival (PubMed:24706757)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name Definition
acetyltransferase activator activity Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
manganese ion binding Binding to a manganese ion (Mn).
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

12 GO annotations of biological process

Name Definition
negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme.
negative regulation of fatty acid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
negative regulation of growth rate Any process that reduces the rate of growth of all or part of an organism.
negative regulation of protein binding Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of catalytic activity Any process that activates or increases the activity of an enzyme.
positive regulation of DNA binding Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cell shape Any process that modulates the surface configuration of a cell.
response to host immune response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTPSHLSDR YELGEILGFG GMSEVHLARD LRLHRDVAVK VLRADLARDP SFYLRFRREA
70 80 90 100 110 120
QNAAALNHPA IVAVYDTGEA ETPAGPLPYI VMEYVDGVTL RDIVHTEGPM TPKRAIEVIA
130 140 150 160 170 180
DACQALNFSH QNGIIHRDVK PANIMISATN AVKVMDFGIA RAIADSGNSV TQTAAVIGTA
190 200 210 220 230 240
QYLSPEQARG DSVDARSDVY SLGCVLYEVL TGEPPFTGDS PVSVAYQHVR EDPIPPSARH
250 260 270 280 290 300
EGLSADLDAV VLKALAKNPE NRYQTAAEMR ADLVRVHNGE PPEAPKVLTD AERTSLLSSA
310 320 330 340 350 360
AGNLSGPRTD PLPRQDLDDT DRDRSIGSVG RWVAVVAVLA VLTVVVTIAI NTFGGITRDV
370 380 390 400 410 420
QVPDVRGQSS ADAIATLQNR GFKIRTLQKP DSTIPPDHVI GTDPAANTSV SAGDEITVNV
430 440 450 460 470 480
STGPEQREIP DVSTLTYAEA VKKLTAAGFG RFKQANSPST PELVGKVIGT NPPANQTSAI
490 500 510 520 530 540
TNVVIIIVGS GPATKDIPDV AGQTVDVAQK NLNVYGFTKF SQASVDSPRP AGEVTGTNPP
550 560 570 580 590 600
AGTTVPVDSV IELQVSKGNQ FVMPDLSGMF WVDAEPRLRA LGWTGMLDKG ADVDAGGSQH
610 620
NRVVYQNPPA GTGVNRDGII TLRFGQ