P9WHR3

PR
Gene name
hip1
Protein name
Serine protease Hip1
Names
Hydrolase important for pathogenesis 1, Serine hydrolase Hip1
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2224c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P9WHR3

Entry ID Method Resolution Chain Position Source
5UGQ X-ray 261 A A 50-520 PDB
5UNO X-ray 260 A A 50-520 PDB
5UOH X-ray 261 A A 50-520 PDB
7SFM X-ray 215 A A 48-520 PDB
8E5W X-ray 215 A A 43-520 PDB
AF-P9WHR3-F1 Predicted AlphaFoldDB

No variants for P9WHR3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WHR3

No associated diseases with P9WHR3

2 regional properties for P9WHR3

Type Name Position InterPro Accession
domain Band 7 domain 95 - 270 IPR001107
domain Menbrane protein HflK, N-terminal 1 - 59 IPR020980

Functions

Description
EC Number
Subcellular Localization
  • Cell envelope
  • Cell membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
envelope A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond.

2 GO annotations of biological process

Name Definition
post-translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
response to host immune response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGMRLSRRDK IARMLLIWAA LAAVALVLVG CIRVVGGRAR MAEPKLGQPV EWTPCRSSNP
70 80 90 100 110 120
QVKIPGGALC GKLAVPVDYD RPDGDVAALA LIRFPATGDK IGSLVINPGG PGESGIEAAL
130 140 150 160 170 180
GVFQTLPKRV HERFDLVGFD PRGVASSRPA IWCNSDADND RLRAEPQVDY SREGVAHIEN
190 200 210 220 230 240
ETKQFVGRCV DKMGKNFLAH VGTVNVAKDL DAIRAALGDD KLTYLGYSYG TRIGSAYAEE
250 260 270 280 290 300
FPQRVRAMIL DGAVDPNADP IEAELRQAKG FQDAFNNYAA DCAKNAGCPL GADPAKAVEV
310 320 330 340 350 360
YHSLVDPLVD PDNPRISRPA RTKDPRGLSY SDAIVGTIMA LYSPNLWQHL TDGLSELVDN
370 380 390 400 410 420
RGDTLLALAD MYMRRDSHGR YNNSGDARVA INCVDQPPVT DRDKVIDEDR RAREIAPFMS
430 440 450 460 470 480
YGKFTGDAPL GTCAFWPVPP TSQPHAVSAP GLVPTVVVST THDPATPYKA GVDLANQLRG
490 500 510
SLLTFDGTQH TVVFQGDSCI DEYVTAYLIG GTTPPSGAKC