P9WHM2
Gene name |
purU |
Protein name |
Formyltetrahydrofolate deformylase |
Names |
Formyl-FH(4) hydrolase |
Species |
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
KEGG Pathway |
mtc:MT3041 |
EC number |
3.5.1.10: In linear amides |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P9WHM2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P9WHM2-F1 | Predicted | AlphaFoldDB |
No variants for P9WHM2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P9WHM2 | |||||
No associated diseases with P9WHM2
4 regional properties for P9WHM2
Functions
| Description | ||
|---|---|---|
| EC Number | 3.5.1.10 | In linear amides |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| formyltetrahydrofolate deformylase activity | Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' IMP biosynthetic process | The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKGSMTAHA | TPNEPDYPPP | PGGPPPPADI | GRLLLRCHDR | PGIIAAVSTF | LARAGANIIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDQHSTAPEG | GTFLQRAIFH | LPGLTAAVDE | LQRDFGSTVA | DKFGIDYRFA | EAAKPKRVAI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MASTEDHCLL | DLLWRNRRGE | LEMSVVMVIA | NHPDLAAHVR | PFGVPFIHIP | ATRDTRTEAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QRQLQLLSGN | VDLVVLARYM | QILSPGFLEA | IGCPLINIHH | SFLPAFTGAA | PYQRARERGV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLIGATAHYV | TEVLDEGPII | EQDVVRVDHT | HTVDDLVRVG | ADVERAVLSR | AVLWHCQDRV |
| IVHHNQTIVF |