P9WGM7

PR
Gene name
mtrA (Rv3246c, MTCY20B11.21c)
Protein name
DNA-binding response regulator MtrA
Names
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv3246c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-164 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P9WGM7

Entry ID Method Resolution Chain Position Source
2GWR X-ray 210 A A 1-228 PDB
3NHZ X-ray 250 A A/B/C/D 1-125 PDB
AF-P9WGM7-F1 Predicted AlphaFoldDB

No variants for P9WGM7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WGM7

No associated diseases with P9WGM7

3 regional properties for P9WGM7

Type Name Position InterPro Accession
domain Signal transduction response regulator, receiver domain 6 - 120 IPR001789
domain OmpR/PhoB-type DNA-binding domain 128 - 227 IPR001867
domain MtrA, receiver domain 6 - 111 IPR047673

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-DNA complex A macromolecular complex containing both protein and DNA molecules.

4 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
metal ion binding Binding to a metal ion.
phosphorelay response regulator activity Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

3 GO annotations of biological process

Name Definition
biological process involved in interaction with host An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDTMRQRILV VDDDASLAEM LTIVLRGEGF DTAVIGDGTQ ALTAVRELRP DLVLLDLMLP
70 80 90 100 110 120
GMNGIDVCRV LRADSGVPIV MLTAKTDTVD VVLGLESGAD DYIMKPFKPK ELVARVRARL
130 140 150 160 170 180
RRNDDEPAEM LSIADVEIDV PAHKVTRNGE QISLTPLEFD LLVALARKPR QVFTRDVLLE
190 200 210 220
QVWGYRHPAD TRLVNVHVQR LRAKVEKDPE NPTVVLTVRG VGYKAGPP