P9WGI5

PR
Gene name
sigB (mysB, Rv2710)
Protein name
RNA polymerase sigma factor SigB
Names
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2710
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P9WGI5

Entry ID Method Resolution Chain Position Source
7PP4 EM 384 A f 1-323 PDB
7Q4U EM 439 A EA/F/KA/L/QA/R/WA/Y 1-323 PDB
7Q59 EM 436 A F/f 1-323 PDB
7ZF2 EM 386 A F 1-323 PDB
AF-P9WGI5-F1 Predicted AlphaFoldDB

No variants for P9WGI5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WGI5

No associated diseases with P9WGI5

10 regional properties for P9WGI5

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 156 - 169 IPR000943-1
domain RNA polymerase sigma-70 180 - 188 IPR000943-2
domain RNA polymerase sigma-70 304 - 316 IPR000943-3
domain RNA polymerase sigma-70 325 - 351 IPR000943-4
domain RNA polymerase sigma-70 region 3 211 - 287 IPR007624
domain RNA polymerase sigma-70 region 2 132 - 201 IPR007627
domain RNA polymerase sigma-70 region 4 300 - 353 IPR007630
domain RNA polymerase sigma-70 region 1.2 91 - 123 IPR009042
domain RNA polymerase sigma factor RpoD, C-terminal 128 - 364 IPR012760
domain RNA polymerase sigma-70 like domain 130 - 353 IPR014284

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
RNA polymerase core enzyme binding Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme.
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

5 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADAPTRATT SRVDSDLDAQ SPAADLVRVY LNGIGKTALL NAAGEVELAK RIEAGLYAEH
70 80 90 100 110 120
LLETRKRLGE NRKRDLAAVV RDGEAARRHL LEANLRLVVS LAKRYTGRGM PLLDLIQEGN
130 140 150 160 170 180
LGLIRAMEKF DYTKGFKFST YATWWIRQAI TRGMADQSRT IRLPVHLVEQ VNKLARIKRE
190 200 210 220 230 240
MHQHLGREAT DEELAAESGI PIDKINDLLE HSRDPVSLDM PVGSEEEAPL GDFIEDAEAM
250 260 270 280 290 300
SAENAVIAEL LHTDIRSVLA TLDEREHQVI RLRFGLDDGQ PRTLDQIGKL FGLSRERVRQ
310 320
IERDVMSKLR HGERADRLRS YAS