AiPD: Autoinhibited Protein Database

Gene name	sigA
Protein name	RNA polymerase sigma factor SigA
Names	Sigma-A
Species	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway	mtu:Rv2703
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

7-85 (Predicted disordered autoinhibitory region) PR

7-85 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
4X8K	X-ray	220 A	A	236-364	PDB
5UH5	X-ray	375 A	F	1-528	PDB
5UH6	X-ray	384 A	F	1-528	PDB
5UH8	X-ray	418 A	F	1-528	PDB
5UH9	X-ray	440 A	F	1-528	PDB
5UHA	X-ray	391 A	F	1-528	PDB
5UHB	X-ray	429 A	F	1-528	PDB
5UHC	X-ray	380 A	F	1-528	PDB
5UHD	X-ray	401 A	F	1-528	PDB
5UHE	X-ray	404 A	F	1-528	PDB
5UHF	X-ray	434 A	F	1-528	PDB
5UHG	X-ray	397 A	F	1-528	PDB
6BZO	EM	338 A	F	1-528	PDB
6C04	EM	327 A	F	1-528	PDB
6C05	EM	515 A	F	1-528	PDB
6C06	EM	515 A	F	1-528	PDB
6EDT	EM	-	F	1-528	PDB
6EE8	EM	392 A	F	1-528	PDB
6EEC	EM	355 A	F	1-528	PDB
6FBV	EM	350 A	F	1-528	PDB
6M7J	EM	440 A	F	1-528	PDB
6ONO	X-ray	185 A	B/D	417-528	PDB
6ONU	X-ray	185 A	B/D/F/H	417-528	PDB
6VVX	EM	339 A	F	1-528	PDB
6VVY	EM	342 A	F	1-528	PDB
6VVZ	EM	372 A	F	1-528	PDB
6VW0	EM	359 A	F	1-528	PDB
7KIF	EM	294 A	F	1-528	PDB
7KIM	EM	338 A	F	1-528	PDB
7KIN	EM	274 A	F	1-528	PDB
7KUF	X-ray	260 A	B	446-528	PDB
7KUG	X-ray	155 A	B/D	446-528	PDB
7U22	X-ray	387 A	F	1-528	PDB
8CWR	X-ray	150 A	B	446-528	PDB
8CWT	X-ray	135 A	B/D/F	446-528	PDB
8CYF	X-ray	244 A	B	446-528	PDB
8D5V	X-ray	180 A	B/D	446-528	PDB
8HIH	EM	366 A	F	1-528	PDB
AF-P9WGI1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P9WGI1

Type	Name	Position	InterPro Accession
domain	RNA polymerase sigma-70	2 - 239	IPR000943
domain	Cro/C1-type helix-turn-helix domain	205 - 225	IPR001387
domain	RNA polymerase sigma-70 region 2	62 - 131	IPR007627
domain	RNA polymerase sigma-70 region 4	180 - 233	IPR007630
domain	RNA polymerase sigma-70 like domain	58 - 234	IPR014284

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
peptidoglycan-based cell wall	A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity	Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

Name	Definition
DNA-templated transcription initiation	The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
response to water	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins