P9WGI0

PR
Gene name
sigA
Protein name
RNA polymerase sigma factor SigA
Names
Sigma-A
Species
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
KEGG Pathway
mtc:MT2777
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P9WGI0

Entry ID Method Resolution Chain Position Source
AF-P9WGI0-F1 Predicted AlphaFoldDB

No variants for P9WGI0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WGI0

No associated diseases with P9WGI0

10 regional properties for P9WGI0

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 319 - 332 IPR000943-1
domain RNA polymerase sigma-70 343 - 351 IPR000943-2
domain RNA polymerase sigma-70 467 - 479 IPR000943-3
domain RNA polymerase sigma-70 488 - 514 IPR000943-4
domain RNA polymerase sigma-70 region 3 374 - 449 IPR007624
domain RNA polymerase sigma-70 region 2 295 - 364 IPR007627
domain RNA polymerase sigma-70 region 4 463 - 516 IPR007630
domain RNA polymerase sigma-70 region 1.2 226 - 259 IPR009042
domain RNA polymerase sigma factor RpoD, C-terminal 291 - 527 IPR012760
domain RNA polymerase sigma-70 like domain 291 - 516 IPR014284

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

1 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAATKASTAT DEPVKRTATK SPAASASGAK TGAKRTAAKS ASGSPPAKRA TKPAARSVKP
70 80 90 100 110 120
ASAPQDTTTS TIPKRKTRAA AKSAAAKAPS ARGHATKPRA PKDAQHEAAT DPEDALDSVE
130 140 150 160 170 180
ELDAEPDLDV EPGEDLDLDA ADLNLDDLED DVAPDADDDL DSGDDEDHED LEAEAAVAPG
190 200 210 220 230 240
QTADDDEEIA EPTEKDKASG DFVWDEDESE ALRQARKDAE LTASADSVRA YLKQIGKVAL
250 260 270 280 290 300
LNAEEEVELA KRIEAGLYAT QLMTELSERG EKLPAAQRRD MMWICRDGDR AKNHLLEANL
310 320 330 340 350 360
RLVVSLAKRY TGRGMAFLDL IQEGNLGLIR AVEKFDYTKG YKFSTYATWW IRQAITRAMA
370 380 390 400 410 420
DQARTIRIPV HMVEVINKLG RIQRELLQDL GREPTPEELA KEMDITPEKV LEIQQYAREP
430 440 450 460 470 480
ISLDQTIGDE GDSQLGDFIE DSEAVVAVDA VSFTLLQDQL QSVLDTLSER EAGVVRLRFG
490 500 510 520
LTDGQPRTLD EIGQVYGVTR ERIRQIESKT MSKLRHPSRS QVLRDYLD