P9WFF7

PR
Gene name
uppS (Rv2361c, MTCY27.19)
Protein name
Decaprenyl diphosphate synthase
Names
DecaPP, Decaprenyl pyrophosphate synthase, Long-chain isoprenyl diphosphate synthase, Trans,polycis-decaprenyl diphosphate synthase
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2361c
EC number
2.5.1.86: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P9WFF7

Entry ID Method Resolution Chain Position Source
2VG2 X-ray 195 A A/B/C/D 13-296 PDB
2VG3 X-ray 180 A A/B/C/D 13-296 PDB
2VG4 X-ray 260 A A/B/C/D 13-296 PDB
4ONC X-ray 183 A A/B 13-296 PDB
6IME X-ray 155 A A/B 1-296 PDB
AF-P9WFF7-F1 Predicted AlphaFoldDB

No variants for P9WFF7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WFF7

No associated diseases with P9WFF7

1 regional properties for P9WFF7

Type Name Position InterPro Accession
conserved_site Di-trans-poly-cis-decaprenylcistransferase-like, conserved site 240 - 257 IPR018520

Functions

Description
EC Number 2.5.1.86 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate.
di-trans,poly-cis-decaprenylcistransferase activity Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).
polyprenyltransferase activity Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor).
Z-farnesyl diphosphate synthase activity Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate.

1 GO annotations of biological process

Name Definition
polyprenol biosynthetic process The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MARDARKRTS SNFPQLPPAP DDYPTFPDTS TWPVVFPELP AAPYGGPCRP PQHTSKAAAP
70 80 90 100 110 120
RIPADRLPNH VAIVMDGNGR WATQRGLART EGHKMGEAVV IDIACGAIEL GIKWLSLYAF
130 140 150 160 170 180
STENWKRSPE EVRFLMGFNR DVVRRRRDTL KKLGVRIRWV GSRPRLWRSV INELAVAEEM
190 200 210 220 230 240
TKSNDVITIN YCVNYGGRTE ITEATREIAR EVAAGRLNPE RITESTIARH LQRPDIPDVD
250 260 270 280 290
LFLRTSGEQR SSNFMLWQAA YAEYIFQDKL WPDYDRRDLW AACEEYASRT RRFGSA