P9WFC7

PR
Gene name
uvrB
Protein name
UvrABC system protein B
Names
Protein UvrB, Excinuclease ABC subunit B
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv1633
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

591-688 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P9WFC7

Entry ID Method Resolution Chain Position Source
AF-P9WFC7-F1 Predicted AlphaFoldDB

No variants for P9WFC7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P9WFC7

No associated diseases with P9WFC7

6 regional properties for P9WFC7

Type Name Position InterPro Accession
domain Helicase, C-terminal 453 - 606 IPR001650
domain UVR domain 674 - 709 IPR001943
domain Helicase/UvrB, N-terminal 39 - 161 IPR006935
domain Helicase superfamily 1/2, ATP-binding domain 32 - 447 IPR014001
domain UvrB, YAD/RRR-motif-containing domain 574 - 615 IPR024759
domain UvrB, interaction domain 182 - 271 IPR041471

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
excinuclease repair complex Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
excinuclease ABC activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind.

4 GO annotations of biological process

Name Definition
induction by symbiont of host immune response Any process in which a symbiont activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction.
nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
response to nitrosative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
SOS response An error-prone process for repairing damaged microbial DNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAFATEHPVV AHSEYRAVEE IVRAGGHFEV VSPHAPAGDQ PAAIDELERR INAGERDVVL
70 80 90 100 110 120
LGATGTGKSA TTAWLIERLQ RPTLVMAPNK TLAAQLANEL REMLPHNAVE YFVSYYDYYQ
130 140 150 160 170 180
PEAYIAQTDT YIEKDSSIND DVERLRHSAT SALLSRRDVV VVASVSCIYG LGTPQSYLDR
190 200 210 220 230 240
SVELKVGEEV PRDGLLRLLV DVQYTRNDMS FTRGSFRVRG DTVEIIPSYE ELAVRIEFFG
250 260 270 280 290 300
DEIEALYYLH PLTGEVIRQV DSLRIFPATH YVAGPERMAH AVSAIEEELA ERLAELESQG
310 320 330 340 350 360
KLLEAQRLRM RTNYDIEMMR QVGFCSGIEN YSRHIDGRGP GTPPATLLDY FPEDFLLVID
370 380 390 400 410 420
ESHVTVPQIG GMYEGDISRK RNLVEYGFRL PSACDNRPLT WEEFADRIGQ TVYLSATPGP
430 440 450 460 470 480
YELSQTGGEF VEQVIRPTGL VDPKVVVKPT KGQIDDLIGE IRTRADADQR VLVTTLTKKM
490 500 510 520 530 540
AEDLTDYLLE MGIRVRYLHS EVDTLRRVEL LRQLRLGDYD VLVGINLLRE GLDLPEVSLV
550 560 570 580 590 600
AILDADKEGF LRSSRSLIQT IGRAARNVSG EVHMYADKIT DSMREAIDET ERRRAKQIAY
610 620 630 640 650 660
NEANGIDPQP LRKKIADILD QVYREADDTA VVEVGGSGRN ASRGRRAQGE PGRAVSAGVF
670 680 690 700 710
EGRDTSAMPR AELADLIKDL TAQMMAAARD LQFELAARFR DEIADLKREL RGMDAAGLK