P98999

PR
Gene name
adcy9
Protein name
Adenylate cyclase type 9
Names
ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, xlAC
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:378610
EC number
4.6.1.1: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P98999

Entry ID Method Resolution Chain Position Source
AF-P98999-F1 Predicted AlphaFoldDB

No variants for P98999

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P98999

No associated diseases with P98999

4 regional properties for P98999

Type Name Position InterPro Accession
domain Adenylyl cyclase class-3/4/guanylyl cyclase 319 - 559 IPR001054-1
domain Adenylyl cyclase class-3/4/guanylyl cyclase 1014 - 1232 IPR001054-2
conserved_site Adenylyl cyclase class-4/guanylyl cyclase, conserved site 492 - 515 IPR018297-1
conserved_site Adenylyl cyclase class-4/guanylyl cyclase, conserved site 1166 - 1189 IPR018297-2

Functions

Description
EC Number 4.6.1.1 Phosphorus-oxygen lyases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
adenylate cyclase-activating adrenergic receptor signaling pathway An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.
adenylate cyclase-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASPVNQQLL HHTEVRCDGS GDGSSVTVRI NRQHHQAPSR RCKYSISSSC SSGESGVKKT
70 80 90 100 110 120
GGSGGARRQK KLPQLFERST SNWWNPKFDS NNLEEACVER CFPQTQRRFR YALMYLSVAG
130 140 150 160 170 180
LLWSIYFSVH MKTKLVSHLV PTLCFLIVCL GFFFFTFTKS YARHCTAISL LVTLLVFTLT
190 200 210 220 230 240
LASQFQVLNP GLGSDSLSNL TSFSATGSSS CLSQVGSFSI CVEVLLLLYT VMHLPLYLSA
250 260 270 280 290 300
CLGVAYSILF ETFGYHFRDE SCFVLLVGRM AHWELLSKAL LHVCIHAIGV HLFIMSEVRS
310 320 330 340 350 360
RSTFLKVGQS IMHGKDLEVE KALKERMIHS VMPRIIADDL MKQGDDESEN SVKRHSASSP
370 380 390 400 410 420
KSRKKKSSIQ KTPIIFRPFK MQRIEQVSIL FADIVGFTKM SANKSAHALV GLLNDLFGRF
430 440 450 460 470 480
DRLCEETKCE KISTLGDCYY CVAGCPEPRP DHAYCCIEMG LGMIEAIDQF CQEKKEMVNM
490 500 510 520 530 540
RVGVHTGTVL CGILGMRRFK FDVWSNDVNL ANLMEQLGVA GKVHISEKTA RYLDDRYLME
550 560 570 580 590 600
DSMVVERLGQ IVAADQLKGL KTFLISGGRT RVPSCSCSQT LIPVQEGTDL SSPSLAPHVQ
610 620 630 640 650 660
AAISETSDSH TNCTQPETLK SCPSCGETAA RDGPEEGVSA ANGGGEEWKG GAPRPSAIGA
670 680 690 700 710 720
SLKDPERSPE SSTGDTLTNS QASLYDMLQE KGRWCGVSMD QSALLPLRFK NIREKTDAHF
730 740 750 760 770 780
VEVIKEDSLM KDYFFKPPIN PLSLNFLDKE LETSYRASYQ EEVIRMAPVK TFASATFSSL
790 800 810 820 830 840
QDVLLNYFIF VLLSVACLLK PGTNTVSPPT LALVLLSVCG LLGFLSLLVS VRMAFYLEDM
850 860 870 880 890 900
LLCTRRLLEI ISGWVPRHFI GTVLVCLPAA VIFSYLSSDF YTDIHYTMFL CSALLIPMVQ
910 920 930 940 950 960
YCNFCQLSSS ALLLATITGA TMLILIYLPL CPQRPPLDPG TDIEANLSTS NSSYETLDNP
970 980 990 1000 1010 1020
RTELPFTRLG QEIAVAYFLL LLLVWFLNRE FDVSYRLHYH GDVEADLHRT KIQSMRDQAD
1030 1040 1050 1060 1070 1080
WLLRNIIPYH VAEQLKVSQS YSKNHDDAGV IFASIVNFSE FYEENYEGGK ECYRALNELI
1090 1100 1110 1120 1130 1140
GDFDELLSKP HYSCIEKIKT IGATYMAASG LNPSQCQDSS QPHRHLQTLF EFAKEMMSVV
1150 1160 1170 1180 1190 1200
DEFNNNMLWF NFKLRIGFNH GPLTAGVIGT TKLLYDIWGD TVNIASRMDT TGVECRIQAS
1210 1220 1230 1240 1250 1260
EESYRVLVKM GYDFDYRGTV NVKGKGQMKT YHFPKCTDNG GLVPHHQLCI SPDIRVQVDG
1270 1280 1290 1300
SIGRSPTDEI SSLVTGGKGA VELGSGEAER KREKAEERGR DGGAR