P97931

PR
Gene name
Ung (Ung1)
Protein name
Uracil-DNA glycosylase
Names
UDG
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:22256
EC number
3.2.2.27: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P97931

Entry ID Method Resolution Chain Position Source
AF-P97931-F1 Predicted AlphaFoldDB

11 variants for P97931

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388775219 23 S>N No EVA
rs3388778727 83 V>M No EVA
rs248854425 126 Q>E No EVA
rs3388782620 143 I>F No EVA
rs48533177 177 K>Q No EVA
rs3412562555 193 D>V No EVA
rs3388788706 205 L>I No EVA
rs3388785786 220 K>M No EVA
rs3388779706 237 Q>R No EVA
rs47284990 277 H>Y No EVA
rs3388782630 288 K>E No EVA

No associated diseases with P97931

2 regional properties for P97931

Type Name Position InterPro Accession
domain Uracil-DNA glycosylase-like 132 - 293 IPR005122
active_site Uracil-DNA glycosylase, active site 140 - 149 IPR018085

Functions

Description
EC Number 3.2.2.27 Hydrolyzing N-glycosyl compounds
Subcellular Localization
  • [Isoform 1]: Mitochondrion
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
damaged DNA binding Binding to damaged DNA.
ribosomal small subunit binding Binding to a small ribosomal subunit.
uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.

7 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
base-excision repair, AP site formation via deaminated base removal A base-excision repair, AP site formation process occurring via excision of a deaminated base.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
isotype switching The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
somatic hypermutation of immunoglobulin genes Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
somatic recombination of immunoglobulin gene segments The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P13051 UNG Uracil-DNA glycosylase Homo sapiens (Human) PR
10 20 30 40 50 60
MIGQKTLYSF FSPTPTGKRT TRSPEPVPGS GVAAEIGGDA VASPAKKARV EQNEQGSPLS
70 80 90 100 110 120
AEQLVRIQRN KAAALLRLAA RNVPAGFGES WKQQLCGEFG KPYFVKLMGF VAEERNHHKV
130 140 150 160 170 180
YPPPEQVFTW TQMCDIRDVK VVILGQDPYH GPNQAHGLCF SVQRPVPPPP SLENIFKELS
190 200 210 220 230 240
TDIDGFVHPG HGDLSGWARQ GVLLLNAVLT VRAHQANSHK ERGWEQFTDA VVSWLNQNLS
250 260 270 280 290 300
GLVFLLWGSY AQKKGSVIDR KRHHVLQTAH PSPLSVHRGF LGCRHFSKAN ELLQKSGKKP
INWKEL