P97852
PR
Gene name |
Hsd17b4 |
Protein name |
Peroxisomal multifunctional enzyme type 2 |
Names |
MFE-2, 17-beta-hydroxysteroid dehydrogenase 4, 17-beta-HSD 4, D-bifunctional protein, DBP, Multifunctional protein 2, MFP-2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:79244 |
EC number |
1.1.1.n12: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P97852
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1GZ6 | X-ray | 238 A | A/B/C/D | 1-319 | PDB |
| AF-P97852-F1 | Predicted | AlphaFoldDB |
No variants for P97852
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P97852 | |||||
No associated diseases with P97852
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.n12 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
12 GO annotations of molecular function
| Name | Definition |
|---|---|
| (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity | Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. |
| 17-beta-hydroxysteroid dehydrogenase (NAD+) activity | Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+. |
| 3-hydroxyacyl-CoA dehydratase activity | Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA). |
| 3-hydroxyacyl-CoA dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). |
| 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity | Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O. |
| enoyl-CoA hydratase activity | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. |
| estradiol 17-beta-dehydrogenase activity | Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. |
| identical protein binding | Binding to an identical protein or proteins. |
| isomerase activity | Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. |
| long-chain-enoyl-CoA hydratase activity | Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| testosterone dehydrogenase [NAD(P)] activity | Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| aging | A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
| androgen metabolic process | The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. |
| cellular response to organic cyclic compound | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. |
| cholesterol metabolic process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
| estrogen metabolic process | The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. |
| fatty acid beta-oxidation | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
| medium-chain fatty-acyl-CoA metabolic process | The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12. |
| response to organic cyclic compound | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. |
| response to steroid hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| Sertoli cell development | The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. |
| very long-chain fatty acid metabolic process | The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. |
| very long-chain fatty-acyl-CoA metabolic process | The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASPLRFDGR | VVLVTGAGGG | LGRAYALAFA | ERGALVVVND | LGGDFKGVGK | GSSAADKVVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIRRRGGKAV | ANYDSVEAGE | KLVKTALDTF | GRIDVVVNNA | GILRDRSFSR | ISDEDWDIIQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVHLRGSFQV | TRAAWDHMKK | QNYGRIIMTA | SASGIYGNFG | QANYSAAKLG | LLGLANTLVI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EGRKNNIHCN | TIAPNAGSRM | TETVMPEDLV | EALKPEYVAP | LVLWLCHESC | EENGGLFEVG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AGWIGKLRWE | RTLGAIVRKR | NQPMTPEAVR | DNWVKICDFS | NASKPKSIQE | STGGIIEVLH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KIDSEGISQN | HTGQVASADA | SGFAGVVGHK | LPSFSSSYTE | LQCIMYALGV | GASVKNPKDL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KFVYEGSADF | SCLPTFGVIV | AQKSLMSGGL | AEVPGLSINF | AKVLHGEQYL | ELYKPLPRSG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELKCEAVIAD | ILDKGSGIVI | VMDVYSYSGK | ELICYNQFSV | FVVGSGGFGG | KRTSEKLKAA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VAVPSRPPDA | VLRDTTSLNQ | AALYRLSGDS | NPLHIDPSFA | SIAGFEKPIL | HGLCTFGFSA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RHVLQQFADN | DVSRFKAIKV | RFAKPVYPGQ | TLQTEMWKEG | NRIHFQTKVQ | ETGDIVISNA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YVDLVPTSGV | SAQTPSEGGA | LQSALVFGEI | GRRLKDVGRE | VVKKVNAVFE | WHITKNGNVA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AKWTIDLKNG | SGEVYQGPAK | GSADTTITIS | DEDFMEVVLG | KLNPQNAFFS | GRLKARGNIM |
| 730 | |||||
| LSQKLQMILK | DYAKL |