P97459
Gene name |
Npas1 |
Protein name |
Neuronal PAS domain-containing protein 1 |
Names |
Neuronal PAS1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18142 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P97459
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5SY5 | X-ray | 320 A | B/D/F | 43-423 | PDB |
| AF-P97459-F1 | Predicted | AlphaFoldDB |
26 variants for P97459
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388864811 | 126 | P>L | No | EVA | |
| rs3388879595 | 129 | L>M | No | EVA | |
| rs3388843396 | 154 | N>K | No | EVA | |
| rs3388878273 | 175 | V>* | No | EVA | |
| rs3388855889 | 177 | L>V | No | EVA | |
| rs3388843419 | 178 | T>P | No | EVA | |
| rs3397804158 | 223 | S>W | No | EVA | |
| rs242454299 | 229 | E>D | No | EVA | |
| rs252951055 | 240 | A>T | No | EVA | |
| rs3388862355 | 285 | V>A | No | EVA | |
| rs3388882385 | 308 | F>L | No | EVA | |
| rs3388874020 | 319 | C>* | No | EVA | |
| rs3388874671 | 338 | S>N | No | EVA | |
| rs6295100 | 356 | L>V | No | EVA | |
| rs3388879609 | 442 | P>S | No | EVA | |
| rs3388862356 | 446 | G>R | No | EVA | |
| rs3397482039 | 447 | K>N | No | EVA | |
| rs3388878331 | 464 | G>S | No | EVA | |
| rs3388862328 | 474 | K>T | No | EVA | |
| rs3388882399 | 482 | S>N | No | EVA | |
| rs214132317 | 492 | A>D | No | EVA | |
| rs3388870225 | 495 | R>W | No | EVA | |
| rs3388855875 | 519 | T>I | No | EVA | |
| rs3388862342 | 520 | P>S | No | EVA | |
| rs3388873999 | 583 | G>W | No | EVA | |
| rs3388862379 | 588 | R>M | No | EVA |
No associated diseases with P97459
5 regional properties for P97459
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PAS domain | 137 - 203 | IPR000014-1 |
| domain | PAS domain | 294 - 405 | IPR000014-2 |
| domain | Myc-type, basic helix-loop-helix (bHLH) domain | 45 - 106 | IPR011598 |
| domain | PAS fold-3 | 317 - 398 | IPR013655 |
| domain | PAS fold | 141 - 198 | IPR013767 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| maternal behavior | Female behaviors associated with the care and rearing of offspring. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| startle response | An action or movement due to the application of a sudden unexpected stimulus. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATPYPRSGG | RGEVKCGGGR | GAGVPWDFLP | GLMVKAPPGP | CLQAQRKEKS | RNAARWRRGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENLEFFELAK | LLPLPGAISS | QLDKASIVRL | SVTYLRLRRF | AALGAPPWGL | RAVGPPAGLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGRRGPVALV | SEVFEQHLGG | HILQSLDGFV | FALNQEGKFL | YISETVSIYL | GLSQVELTGS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVFDYIHPGD | HSEVLEQLGL | RAASIGPPTP | PSVSSSSSSS | SSSLVDTPEI | EASPTEASPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FRAQERSFFV | RMKSTLTKRG | LNVKASGYKV | IHVTGRLRAR | ALGLVALGHT | LPPAPLAELP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LHGHMIVFRL | SLGLTILACE | SRVSDHMDMG | PSELVGRSCY | QFVHGQDATR | IRQSHLDLLD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KGQVVTGYYR | WLQRAGGFVW | LQSVATVAGN | GKSTGEHHVL | WVSHVLSNAE | GSQTPLDAFQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LPAIVSQEEP | SRPGPEPTEE | EPPVDGKQAV | PADQDKDKDP | QARGKRIKVE | ASPKEARGSE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DSGEEELSDP | PAPPRPEFTS | VIRAGALKHD | PVLPWGLTTP | GDPSPALLHA | GFLPPVVRGL |
| 550 | 560 | 570 | 580 | 590 | |
| CTPGTIRYGP | AELSLMYPHL | HRLGAGPSLP | EAFYPTLGLP | YPGPTGTRVQ | RKGD |