P96318

PR
Gene name
icd
Protein name
Isocitrate dehydrogenase [NADP]
Names
IDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase
Species
Caldococcus noboribetus
KEGG Pathway
EC number
1.1.1.42: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P96318

Entry ID Method Resolution Chain Position Source
AF-P96318-F1 Predicted AlphaFoldDB

No variants for P96318

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P96318

No associated diseases with P96318

3 regional properties for P96318

Type Name Position InterPro Accession
binding_site Rubredoxin, iron-binding site 55 - 65 IPR018527
domain Rubredoxin-like domain 23 - 74 IPR024934
domain Rubredoxin domain 25 - 73 IPR024935

Functions

Description
EC Number 1.1.1.42 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
isocitrate dehydrogenase (NADP+) activity Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.
magnesium ion binding Binding to a magnesium (Mg) ion.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

2 GO annotations of biological process

Name Definition
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVSHPCTADE AKPPSEGQLA RFENGKLIVP DNLIVAYFKG DGIGPEIVES AKKVLDAAVD
70 80 90 100 110 120
KAYGGTRRIV WWEVTAGEEA QKECGSLLPD GTLQAFKLAR VNLKGPLTTP VGGGFRSLNV
130 140 150 160 170 180
TLRMVLDLYS NVRPVKWYGQ PTPHCHPENI DWVIFRENTE DVYAGIEWPF DSPEAQKIRD
190 200 210 220 230 240
FLKKEFGIEL TPDTGIGIKP ISKWRTQRHV RRAMEWAIRN GYKHVTIMHK GNIMKYTEGA
250 260 270 280 290 300
FRQWAYDLIL SEFRDYVVTE EEVNTKYGGK APEGKIIVND RIADNMLQQI ITRPGEYNVI
310 320 330 340 350 360
VTPNLNGDYI SDEANALVGG IGMAAGLDMG DGIAVAEPVH GSAPKYAGKN VINPTAEILS
370 380 390 400 410 420
GMYLLSDFVG WPEVKLLVEY AVKQAIAHKQ VTYDLAREMG GVTPISTTEY TDVLVDYIRH
ADLKALKGQ