P96123
Gene name |
mtnN (mtn, TP_0170) |
Protein name |
Chemotaxis protein CheA |
Names |
|
Species |
Treponema pallidum (strain Nichols) |
KEGG Pathway |
tpa:TP_0363 |
EC number |
2.7.13.3: Protein-histidine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P96123
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P96123-F1 | Predicted | AlphaFoldDB |
No variants for P96123
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P96123 | |||||
No associated diseases with P96123
10 regional properties for P96123
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CheW-like domain | 653 - 798 | IPR002545 |
| domain | Histidine kinase/HSP90-like ATPase | 520 - 661 | IPR003594 |
| domain | Histidine kinase CheA-like, homodimeric domain | 350 - 475 | IPR004105 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 565 - 579 | IPR004358-1 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 605 - 615 | IPR004358-2 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 621 - 639 | IPR004358-3 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 645 - 658 | IPR004358-4 |
| domain | Histidine kinase domain | 456 - 661 | IPR005467 |
| domain | Signal transduction histidine kinase, phosphotransfer (Hpt) domain | 7 - 111 | IPR008207 |
| domain | Chemotaxis protein CheA, P2 response regulator-binding | 198 - 277 | IPR010808 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.13.3 | Protein-histidine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| phosphorelay sensor kinase activity | Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPMSDYLDAG | NEELLKDFFS | EAEQQVEQLE | SNILVIEQDP | TNRDAVDEIF | RAAHTLKGGA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ATVEMHELSG | FTHAVEDLLD | GIRSEKVTVD | GAVVDLLLTS | LDVIKAMLES | RAGGGPYAED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSDLVARLRS | YLPASGTVPG | AARGLSVSSP | NAAEAAKGTA | VGEDGTEAPQ | VGRVPPLSLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SEYDRLELRE | IVPPEHSVYA | LTVRFDESNL | MNTVGGIQVF | TALKSCASVL | KTVPDFDALY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QDMFHEYVVY | FVSTVQDSVC | VSQVASIPDV | TLSVSVAEVA | LADLCTPLSE | HGELGVCADA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GTGGVSEGSG | AAVRSGGERV | PNSLPKQVAG | CAVPSAKDSS | KATSSGYGSG | SVLRVDAKRI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DYLLNLVSET | VIIKASLNQS | ALEFGEVYTL | FQNANGAYKE | RLRKFFDRVP | AYLEKVKNGQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DADAVRKGMI | AEAVGVFDIF | SSFENGLKQS | VTKFRSSAQN | LGRISGELQE | GVMKIRMVPI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SQIFSRYPRV | VRDLSRDLRK | EVRLVIEGEE | TELDKSVVED | LLDPIMHCVR | NSLDHGIEAP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EVRARSGKPA | QGTLLLRASN | EGNMIVIEVA | DDGRGIDVEA | VKTKAVERGV | LHPGKNLTEV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EAFQLIFAPG | FSTSRSVSNV | SGRGVGLDVV | KTHIERLNGT | VSVFSEVQKG | TRFVIKLPLT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LAIIQGLLIR | VGQEVYSIPI | ASVIESHRIK | SEEINRIDNY | EVFNVRNEVI | SLLRLDRLFG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ISCDDEVTGQ | YHYVVIVGAA | EKKVGLMVDA | LIGEEDVVIK | PLRDQFTSSP | GIAGASILGD |
| 790 | 800 | 810 | |||
| GSVSLIIDVG | QLLELGLKRE | ILARERREAT | VW |