P95968

PR
Gene name
gltX
Protein name
Glutamate--tRNA ligase
Names
Glutamyl-tRNA synthetase, GluRS
Species
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
KEGG Pathway
sso:SSO0093
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P95968

Entry ID Method Resolution Chain Position Source
AF-P95968-F1 Predicted AlphaFoldDB

No variants for P95968

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P95968

No associated diseases with P95968

2 regional properties for P95968

Type Name Position InterPro Accession
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 101 - 413 IPR020058
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain 416 - 561 IPR020059

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

2 GO annotations of biological process

Name Definition
amide biosynthetic process The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMELNELRET IYKYALQNAV KHNGKAETGP VMSKIIAERP ELRSNAREIV KIIKEIIEQV
70 80 90 100 110 120
NSLTLEQQLT EIKAKYPELL EEKKHEEKRK VLPPLPNVKG QVVTRFAPNP DGPLHLGNAR
130 140 150 160 170 180
SAILSYEYAK MYNGKFILRF DDTDPKVKRP ILDAYDWIKE DLKWLGIKWE QELYASERLE
190 200 210 220 230 240
LYYKYARYLI EKGYAYVDTC DSSIFRKFRD SRGKMKEPEC LHRSSSPESN LELFEKMLGG
250 260 270 280 290 300
KFKEGEAVVR LKTDLSDPDP SQIDWVMLRI IDTAKNPHPR VGSKYWVWPT YNFASIIDDH
310 320 330 340 350 360
ELGITHVLRA KEHMSNTEKQ RYISEYMGWE FPEVLQFGRL RLEGFMMSKS KIRGMLEKGT
370 380 390 400 410 420
NRDDPRLPTL AGLRRRGILP DTIKDVIIDV GVKVTDATIS FENIAAINRK KLDPVAKRIM
430 440 450 460 470 480
FVKDAEEFSV ELPESLNAKI PLIPSKQEMN RTIIVNPGDK ILIESNDAED NSILRLMELC
490 500 510 520 530 540
NVKVDKHNRK LIFHSKTLDE AKKVNAKIVQ WVKSNEKVPV MVEKAERDEI KMINGYAEKI
550 560 570
AADLEIDEIV QFYRFGFVRV DRKDENMLRV VFSHD