P91929
Gene name |
ND-42 |
Protein name |
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial |
Names |
Complex I-42kD, CI-42kD, NADH-ubiquinone oxidoreductase 42 kDa subunit |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG6343 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for P91929
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8B9Z | EM | 328 A | O | 40-407 | PDB |
| 8BA0 | EM | 368 A | O | 40-407 | PDB |
| 8ESW | EM | 330 A | AL | 1-407 | PDB |
| 8ESZ | EM | 340 A | AL | 1-407 | PDB |
| AF-P91929-F1 | Predicted | AlphaFoldDB |
No variants for P91929
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P91929 | |||||
No associated diseases with P91929
1 regional properties for P91929
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Deoxynucleoside kinase domain | 85 - 316 | IPR031314 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrial respiratory chain complex I | A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial electron transport, NADH to ubiquinone | The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTAVFRVGLV | RLVSRATQSP | NLLQAQTNAL | PAAFQQRCSI | SGKTMRGGPR | VPKAAPYPYK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TKKYSVFNAI | FDKTSKRFDE | NSKVICVEGP | IAAGKSKFAK | ELAEELDMEY | YPAVDLDLIY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INSYGYDMRK | LDPQLPPSCR | SYDVRNFCLD | PSHDLAAQFQ | IRMYMLRYSQ | YIDALQHVLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGQGVVLERS | PYSDFVFMEA | MFRQGYLSRG | ARSVYNELRQ | NTIGELLKPH | LVIYLDLPVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVKKQIKARN | VDYEVQSKVF | SDAYLSDLEQ | LYKQQYLKDI | STHAELLIYD | WTAGGETEVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEDIERIDFN | QFEADIHNKK | MLDWRFPLEA | EWCEARIKYC | HEKPDLMNYF | NVPRFDVPEL |
| 370 | 380 | 390 | 400 | ||
| VRSADDGKVW | RDVWFNAPGM | KYRPGYNADM | GDEGLLTKTK | IGINQGI |