P91660
PR
Gene name |
Rh5 (CG5279) |
Protein name |
Probable multidrug resistance-associated protein lethal(2)03659 |
Names |
Wunen region A protein |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG8799 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P91660
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P91660-F1 | Predicted | AlphaFoldDB |
No variants for P91660
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P91660 | |||||
No associated diseases with P91660
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| efflux transmembrane transporter activity | Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. |
| organic anion transmembrane transporter activity | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| organic anion transport | The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
26 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8HXQ5 | ABCC1 | Multidrug resistance-associated protein 1 | Bos taurus (Bovine) | PR |
| Q2QLE5 | CFTR | Cystic fibrosis transmembrane conductance regulator | Pan troglodytes (Chimpanzee) | PR |
| Q5U820 | CFTR | Cystic fibrosis transmembrane conductance regulator | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q2QLA3 | CFTR | Cystic fibrosis transmembrane conductance regulator | Equus caballus (Horse) | PR |
| O95255 | ABCC6 | ATP-binding cassette sub-family C member 6 | Homo sapiens (Human) | PR |
| O15438 | ABCC3 | ATP-binding cassette sub-family C member 3 | Homo sapiens (Human) | PR |
| Q92887 | ABCC2 | ATP-binding cassette sub-family C member 2 | Homo sapiens (Human) | SS |
| Q96J66 | ABCC11 | ATP-binding cassette sub-family C member 11 | Homo sapiens (Human) | PR |
| P33527 | ABCC1 | Multidrug resistance-associated protein 1 | Homo sapiens (Human) | PR |
| P13569 | CFTR | Cystic fibrosis transmembrane conductance regulator | Homo sapiens (Human) | PR |
| O15439 | ABCC4 | ATP-binding cassette sub-family C member 4 | Homo sapiens (Human) | PR |
| B2RX12 | Abcc3 | ATP-binding cassette sub-family C member 3 | Mus musculus (Mouse) | PR |
| Q8VI47 | Abcc2 | ATP-binding cassette sub-family C member 2 | Mus musculus (Mouse) | SS |
| O35379 | Abcc1 | Multidrug resistance-associated protein 1 | Mus musculus (Mouse) | PR |
| Q80WJ6 | Abcc12 | ATP-binding cassette sub-family C member 12 | Mus musculus (Mouse) | PR |
| P26361 | Cftr | Cystic fibrosis transmembrane conductance regulator | Mus musculus (Mouse) | PR |
| Q6PQZ2 | CFTR | Cystic fibrosis transmembrane conductance regulator | Sus scrofa (Pig) | PR |
| Q6Y306 | Abcc12 | ATP-binding cassette sub-family C member 12 | Rattus norvegicus (Rat) | PR |
| Q8CG09 | Abcc1 | Multidrug resistance-associated protein 1 | Rattus norvegicus (Rat) | PR |
| Q63120 | Abcc2 | ATP-binding cassette sub-family C member 2 | Rattus norvegicus (Rat) | EV |
| Q00553 | CFTR | Cystic fibrosis transmembrane conductance regulator | Macaca mulatta (Rhesus macaque) | PR |
| Q9C8G9 | ABCC1 | ABC transporter C family member 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C8H0 | ABCC12 | ABC transporter C family member 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SKX0 | ABCC13 | ABC transporter C family member 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZZ4 | ABCC6 | ABC transporter C family member 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1C7 | ABCC9 | ABC transporter C family member 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDKQPVLEPT | FDSVSERENT | SIEESSLLEN | NGFDHRNKDE | SLSVNTSPPL | VCRKCFELGH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QTENCKQKLT | VNSENNSAQN | EKEKVLPENP | RARSNFISSL | CFWYTIPIFR | KGYRKTLDST |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLYRPLEEQK | SDILGNRLCA | SWERELKNDG | RSPSLVRALL | RVFGWQLGFP | GLAIFVVELG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRTLQPIFLV | KLISYFSGEP | DAANAGFYYA | VAQIVISALT | VMILTPTTFG | IHHVCFKMRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AMGSMIFRKA | LRLTKGALGD | TTSGHVVNLI | SNDIPRLDSA | PYTVHYLWVG | PLQVLVITYL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MYQEIGISAV | FGVLFMLLFM | PIQMYLGTRT | SAIQLKAAER | TDNRIRMVNE | IISAIQVLKM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YAWEQPFEQM | VTHAREKEMN | TIRQGQYIRG | FDFARRIVLS | RVAIFLSLVG | YVILGKVFTP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EIAFMITAYY | NVLLAAMSIY | VPSAIIQTAQ | FLTSIRRVEQ | FMQSEELGSS | DKSEGPSKDT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VPGNPPSNNN | EADLLKSAIS | IRDLKAKWDP | NSPDYTLSGI | NLEIKPGSVV | AVIGLTGSGK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SSLIQAILGE | LKANSGQLQV | NGSLSYTSQE | SWLFSGTVRQ | NILFGQPMDS | QRYEEVVKKC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ALERDFDLLP | LRDNTIVGER | GATLSGGQKA | RISLARSVYR | KASIYLLDDP | LSAVDASVAR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HLFDQCVRGH | LRGSTVVLVT | HQEQFLPHVD | QIVILANGQI | KALGDYESLL | KTGLITGLGS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LSKTDKAKTE | EQEPLNLNSP | DNKNEVTPIK | ENSEQTVGGS | SSGKEHVERQ | ESGGISLALY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RKYFQAGGGL | VAFLVMLSSS | VLAQVAVTGG | DYFLTYWVKK | ESTAAGHGEM | EDMESKSMDV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YKYTLIIILS | VIMNLSSSFL | LFNIAKKASI | RLHNTIFNRV | TRADMHFFSI | NKHGSILNRF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TKDMSQVDEV | LPVVLVDVMQ | IALWLAGIII | VIANVNPLLL | VPTLMLSVIF | YHLRNLYLKT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SRDLKRVEAI | NRSPVYSHLA | ASLNGLTTIR | ALDAQRVLEK | EFDSYQDAHS | SAFFMYISTS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| QAFGYCMNCI | CVIYISIITL | SFFAFPPGNG | ADVGLVITQA | MGLIDMVQWG | VRQTAELENT |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| MTAVERVVEY | ESIEPEGMLE | APDDKKPPKT | WPEQGEIIFK | ELNLRYTPNA | KAENVLKSLS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| FVIQPREKVG | IVGRTGAGKS | SLINALFRLS | YTDGSVLIDT | RDTRQMGLHD | LRRQISIIPQ |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| EPVLFSGTMR | YNLDPFDEYS | DEKLWGCLEE | VKLKEVVSDL | PDGLASKISE | GGTNFSVGQR |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| QLVCLARAIL | RENRILVMDE | ATANVDPQTD | GLIQATIRSK | FRDCTVLTIA | HRLHTIIDSD |
| 1330 | 1340 | 1350 | 1360 | 1370 | |
| KVMVMDAGRV | VEFGSPYELM | TKSDSKVFHN | LVNQSGRASY | EGLLKIAQET | FESS |