P91641

PR
Gene name
grn (Gata-c, CG9656)
Protein name
Mediator of RNA polymerase II transcription subunit 20
Names
Mediator complex subunit 20, Protein trf-proximal, dMED20, dTrap26, dTrfp
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG18780
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P91641

Entry ID Method Resolution Chain Position Source
AF-P91641-F1 Predicted AlphaFoldDB

No variants for P91641

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P91641

No associated diseases with P91641

No regional properties for P91641

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P91641

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

2 GO annotations of biological process

Name Definition
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGVTILQPYP LPEGKSGAHI IDQLSKRLLA LGATHAGQFL VDCETFISTP QPHNGAPGRA
70 80 90 100 110 120
VHVLHNSEYP ASTFSIIDNG TGKQVAIVAD NIFDLLMLKM TNTFTSKKQT KIESRGARFE
130 140 150 160 170 180
YGDFVIKLGS VTMMEHFKGI LIEIEYKSCV ILAYCWEMIR EMLQGFLGIA VNKDFPSYFA
190 200 210 220 230 240
PQTIMTAMGQ QQLHAKHNDI FEPMDTVKQY LEQFTNYRKH VTLMGGMGSG PGSQQVGPNV
250
HMSPAVAGLH RS