P90740
Gene name |
uaf-1 (CBG15152) |
Protein name |
Fanconi-associated nuclease 1 homolog |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C01G5.8 |
EC number |
3.1.4.1: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P90740
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P90740-F1 | Predicted | AlphaFoldDB |
No variants for P90740
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P90740 | |||||
No associated diseases with P90740
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.1 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-3' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. |
| 5'-flap endonuclease activity | Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. |
| flap-structured DNA binding | Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule. |
| metal ion binding | Binding to a metal ion. |
| phosphodiesterase I activity | Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| interstrand cross-link repair | Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKKAKKEKKE | KIIKPDGPIN | FNRSIMAAFE | KQSRGKICPL | CETKFSLASY | KSHMNTCNVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDDEEIEVIA | TYTRDEAILM | RAGPEIILGD | ASFSDKSENP | TKRRKTDERE | VPSEDDIVPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPGPSGIVKN | HEMPSESLDV | TEISENIEKV | IKKSPEWINH | RRRSSRLLQN | SQKDQADNAN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KEDPVKKETA | TISEVLQAIE | RFEQRVSGPE | QTWPYYIKIT | IKIMKRVIST | EKFDGTFYAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DFWLPSDIIT | FYRFVELLSE | GAKCLLVRLF | IRKPAWYNLE | KLEQKYPEIP | NIKEAVSELA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KGHFIDDDSS | MKTLDEALQI | SDVVALKNVT | KKFKLDGTKN | RQELIQSLRK | FAQSQQSIFG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GTGNVEKSIL | KSLKQELGPC | VRVRGGFVDL | FKCLFTIYCP | VTTNSANVID | NPSTTNVYQD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLYLMLSVAN | GTVQFPAPNP | CPIIASFYKN | RNMLQDYMIS | KSLEIAIVSQ | MSNGNLDAAL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DLAIDAKEFI | EQMSDDDKRY | YESLEIHERK | FTSIWVFTRC | CGHASSILER | QKKYGMAVEW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QKDLLITNKD | IQSYCIDSRG | IWWDRMLLNL | DSHLKEKKEC | AKMIQIALQD | PSILEKELLM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IQDRALKLKE | MPADFVTPIN | IGNPEKKTIT | ANVITKSLGD | GRINRFMIRD | HETDDDVECS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VEEVTRRHYL | ENEGFSTGVH | DEGSTWHTLF | GLFFYDVIFA | TDESVESTWL | SELQDCPSDL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SNTLYSKRKE | KFEDRFVWLE | EAEQELIEEN | IRKIWDLKHN | ETNRECSWKQ | FPMGAEDCVS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FFQCIPRPAL | ILILRRLAEN | YRNSRSGFPD | LTLWNPETKR | VAVVEVKGPG | DRLSTKQRLW |
| 850 | 860 | ||||
| LAIFADSGIR | AEVCHVAAQN | SRLLV |