P89946

PR
Gene name
YEL075W-A (YEL076W-C)
Protein name
Structural polyprotein
Names
p130
Species
Barmah forest virus (BFV)
KEGG Pathway
vg:1489701
EC number
3.4.21.90: Serine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P89946

Entry ID Method Resolution Chain Position Source
2YEW EM 500 A PDB

2 variants for P89946

Variant ID(s) Position Change Description Diseaes Association Provenance
826 G>A No
1020 K>R No

No associated diseases with P89946

3 regional properties for P89946

Type Name Position InterPro Accession
domain Peptidase S3, togavirin 96 - 254 IPR000930
domain Alphavirus E3 spike glycoprotein 263 - 321 IPR002533
domain Alphavirus E1 glycoprotein 742 - 1235 IPR002548

Functions

Description
EC Number 3.4.21.90 Serine endopeptidases
Subcellular Localization
  • [Capsid protein]: Virion
  • Host cytoplasm
  • Host cell membrane
  • Host nucleus
  • Shuttles between the cytoplasm and the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
host cell plasma membrane The plasma membrane surrounding a host cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
T=4 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres.
virion membrane The lipid bilayer surrounding a virion.

3 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

5 GO annotations of biological process

Name Definition
fusion of virus membrane with host endosome membrane Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
suppression by virus of host toll-like receptor signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism.
viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
virion attachment to host cell The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDFIPTQTFY GRRWRPAPVQ RYIPQPQPPA PPRRRRGPSQ LQQLVAALGA LALQPKQKQK
70 80 90 100 110 120
RAQKKPKKTP PPKPKKTQKP KKPTQKKKSK PGKRMRNCMK IENDCIFPVM LDGKVNGYAC
130 140 150 160 170 180
LVGDKVMKPA HVKGTIDNPE LAKLTFKKSS KYDLECAQVP VCMKSDASKF THEKPEGHYN
190 200 210 220 230 240
WHHGAVQFSN GRFTIPTGSG KPGDSGRPIF DNTGKVVAIV LGGANEGART ALSVVTWNKD
250 260 270 280 290 300
MVTRITPEES VEWSAAALNI TALCVLQNLS FPCDAPPCAP CCYEKDPAGT LRLLSDHYYH
310 320 330 340 350 360
PKYYELLDST MHCPQGRRPK RSVAHFEAYK ATRPYIGWCA DCGLAGSCPS PVSIEHVWSD
370 380 390 400 410 420
ADDGVLKIQV SMQIGIAKSN TINHAKIRYM GANGVQEAER STLSVSTTAP CDILATMGHF
430 440 450 460 470 480
ILARCRPGSQ VEVSLSTDPK LLCRTPFSHK PRFIGNEKSP APTGHKTRIP CKTYSHQTDL
490 500 510 520 530 540
TREEITMHVP PDVPIQGLVS NTGKSYSLDP KTKTIKYKCT CGETVKEGTA TNKITLFNCD
550 560 570 580 590 600
TAPKCITYAV DNTVWQYNSQ YVPRSEVTEV KGKIHVPFPL TDSTCAVSVA PEPQVTYRLG
610 620 630 640 650 660
EVEFHFHPMY PTLFSIRSLG KDPSHSQEWI DTPMSKTIQV GAEGVEYVWG NNNPVRLWAQ
670 680 690 700 710 720
KSSSSSAHGN PISIVSHYYD LYPYWTITVL ASLGLLIVIS SGFSCFLCSV ARTKCLTPYQ
730 740 750 760 770 780
LAPGAQLPTF IALLCCAKSA RADTLDDFSY LWTNNQAMFW LQLASPVAAF LCLSYCCRNL
790 800 810 820 830 840
ACCMKIFLGI SGLCVIATQA YEHSTTMPNQ VGIPFKALIE RPGYAGLPLS LVVIKSELVP
850 860 870 880 890 900
SLVQDYITCN YKTVVPSPYI KCCGGAECSH KNEADYKCSV FTGVYPFMWG GAYCFCDTEN
910 920 930 940 950 960
SQMSEVYVTR GESCEADHAI AYQVHTASLK AQVMISIGEL NQTVDVFVNG DSPARIQQSK
970 980 990 1000 1010 1020
FILGPISSAW SPFDHKVIVY RDEVYNEDYA PYGSGQAGRF GDIQSRTVNS TDVYANTNLK
1030 1040 1050 1060 1070 1080
LKRPASGNVH VPYTQTPSGF SYWKKEKGVP LNRNAPFGCI IKVNPVRAEN CVYGNIPISM
1090 1100 1110 1120 1130 1140
DIADAHFTRI DESPSVSLKA CEVQSCTYSS DFGGVASISY TSNKVGKCAI HSHSNSATMK
1150 1160 1170 1180 1190 1200
DSVQDVQESG ALSLFFATSS VEPNFVVQVC NARITCHGKC EPPKDHIVPY AAKHNDAEFP
1210 1220 1230
SISTTAWQWL AHTTSGPLTI LVVAIIVVVV VSIVVCARH