P89678

PR
Gene name
ORF2a
Protein name
RNA-directed RNA polymerase 2a
Names
2a pol, 2a polymerase
Species
Tobacco streak virus (strain WC) (TSV)
KEGG Pathway
vg:962656
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

79-171 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P89678

Entry ID Method Resolution Chain Position Source

No variants for P89678

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P89678

No associated diseases with P89678

3 regional properties for P89678

Type Name Position InterPro Accession
domain RNA-dependent RNA polymerase, alsuviricetes 253 - 682 IPR001788
domain RNA-directed RNA polymerase, catalytic domain 459 - 574 IPR007094
domain RNA-dependent RNA polymerase, bromovirus 255 - 626 IPR047309

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

2 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
viral RNA genome replication The replication of a viral RNA genome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDLVIKNLIV YHLRRRIDIG TSFGIEPADY IDWVKVFLLK FIIEHTARFA DFATIHTTML
70 80 90 100 110 120
LVLGEDDPNY VEKDTPIMEI DPFYLPYDDL DVDYTSLRVC GDEDQSCSDR DELSDFISNI
130 140 150 160 170 180
SHIPEGTSWG SESDTSFVEH LETIQDIPTK CEIADKPVEE IPFDDDGKVV NDVWVDAELS
190 200 210 220 230 240
NAPEISCDAD IRACGFVSLR LLESSRGYPK WTPERVSSGL NPDLPVNSKP AVDEIFPHHH
250 260 270 280 290 300
SVDDRFFQEW VETHDIDLEV TSCDLDMSTF NDWTKGVDTR LVPNMSVGGL SHRVPTQREA
310 320 330 340 350 360
LLAIKKRNMN VPELQSNFDH DDVLNRCVTR FITHVVDKTR LSKLNPISGE ELHYFNQYLE
370 380 390 400 410 420
NKNPPLSEYK GPVPLVALDK YMHMIKTTLK PVEEDNLHIE RPIPATITYH KKGVVMMTSP
430 440 450 460 470 480
YFLCAMVRLL YVLKSKFVVP TGKYHQIFQM NPELLKHSKE FKEIDFSKFD KSQGRLHHDV
490 500 510 520 530 540
QFRLFLALGI PEHFVTTWFN SHEKSYIRDR DCGIGFSVDY QRRTGDACTY LGNTLVTLSV
550 560 570 580 590 600
LSYVYDLSNP NILFVAASGD DSLIGSIEPL PREKEDLCVS LFNFETKFPH NQPFICSKFL
610 620 630 640 650 660
LVVECDDGSE EVLAVPNPLK LLQKLGPKNL QVTVLDDYYQ SLCDILWVFN DADVCRRTAE
670 680 690 700 710 720
LAEYRRFKGT KKCLFLESAL LSLPSLVANR MKFVRRTINL ESSRACIRND VYSDLVPHFD
730 740 750 760 770 780
SRVSRCDDSD GVRTSTFDDR KSSKHASDKL RKTECYGEAR CRIKPRRNRK SESGAVQYSQ
790
SSGIETGKAN SSRKGRIKLH